Node summary

Genes16721
Ancestral nodeBOP9

Download summaries for ALL nodes as:

CAFE summary

Expansions241 (13 rapid)
Contractions297 (6 rapid)
Extinctions153

Download text lists:

Click tab to see table

(The tables may take a second to load)

Family IDGene CountChangeRapid (*)?Exctinction (--)?
2716+1
2737+1
92560-1--
908-2*
9511-1
9419+1
9711-1
11773+1
8763-1
8754+1
85490-1--
8704+1
6245+2
3925+1
3903-1
23021-1
37482+1
1759+1
1708+1
103960-1--
97520-1--
97580-1--
6995+1
2585-1
2528+2*
2516+1
2557+1
95090-1--
95030-1--
95050-1--
25101-1
25131-1
101820-1--
101890-1--
11583+1
11502-1
85260-1--
21861-1
21851-1
27272+1
97770-1--
97700-1--
2345-1
2374-1
2307+1
2334-1
95670-1--
9332-1
93980-1--
21453+1
7984+1
24150-1--
11333+1
11303+1
288+3
19261-1
27032+1
91730-1--
97140-1--
34712+1
90020-1--
94540-1--
91042+1
94570-1--
2187+1
25580-2*--
9184+1
9152-1
9144+1
12113+1
11173+1
19512+1
1935-1
27692+1
91510-1--
91500-1--
27602+1
27652+1
97390-1--
660+1
74662+1
13053+1
4993-1
4905+1
4925+1
4933-1
4468+3*
25752+1
25722+1
25702+1
9782-1
89240-1--
89280-1--
3188+2*
22973+1
22941-1
91380-1--
34382+1
34392+1
8782-1
8734+1
52042+1
10943+1
77370-1--
9512-1
9542-1
9562-1
96700-1--
5904+1
5994+1
5984+1
28262+1
15431-1
94460-1--
91140-1--
95300-1--
4543-1
4556+2*
95730-1--
24651-1
24672+1
24681-1
10214+1
10202-1
96560-1--
93060-1--
95780-1--
5703-1
14233+1
85800-1--
3534-1
86770-1--
22532+1
94620-1--
97930-1--
98080-1--
4795+1
2976+1
2944-1
2926+1
5815+2
104110-1--
96390-1--
96320-1--
96330-1--
96350-1--
14323+1
5593-1
28662+1
5563-1
5523-1
11932-1
3725+1
22773+1
20511-1
20543+1
13875+3*
81070-1--
24201-1
93420-1--
21621-1
28462+1
5364-1
5393-1
75472+1
10171-1
10122-1
94970-1--
24091-1
6142-1
6153-1
20623+1
5165+1
12264+1
87920-1--
38782+1
38790-1--
75650-1--
22343+1
22361-1
34972+1
20991-1
368+3
90092+1
77970-1--
10373+1
23951-1
18563+1
21751-1
49602+1
103770-1--
75822+1
10623+1
59122+1
26172+1
100260-1--
29492+1
10502-1
10512-1
86470-1--
86420-1--
17023+1
21351-1
23792+1
23712+1
21101-1
8832-1
95830-1--
100190-1--
100180-1--
98890-1--
12633+1
87820-1--
76102+1
76122+1
85140-1--
85130-1--
25832+1
2807+1
26342+1
95960-1--
92220-1--
7605+2*
23581-1
18913+1
27873+1
100210-1--
17963+1
94690-1--
98430-1--
38910-1--
92000-1--
35652+1
7084+1
1478+1
7054+1
85770-1--
5686+2*
23373+1
12111+1
1248-2
1268-1
104030-1--
82100-1--
81770-1--
33942+1
2626+1
2606+1
2657+1
2646+1
92630-1--
9862-1
9873+1
90810-1--
100080-1--
26762+1
31752+1
7264+1
11643+1
11693+1
85520-1--
23150-1--
10212+1
10611-1
1059-1
100010-1--
12823+1
6883-1
2435-1
95310-1--
21563+1
3385+1
26903+2*
11443+1
3805+1
3816+1
3823-1
3843-1
37552+1
21961-1
1695-1
1655-1
1619+1
16215+7*
27352+1
27302+1
103680-1--
103620-1--
97600-1--
92870-1--
15573+1
2297+1
2228+1
25052+1
95110-1--
101940-1--
101990-1--
11223+1
11262-1
85180-1--
103540-1--
1447+1
14210+1
1409-1
27022+1
27132+1
33452+1
91600-1--
8252-1
8273-1
8224+1
81630-1--
41892+1
1146+3
1047+2
1243+1
1634+1
1833+1
2017+1
2038+2*
8314+1
36572+1
25282+1
95750-1--
9203+1
7874+1
4043-1
11042-1
18963+1
465-1
27702+1
30790-2*--
56452+1
25401-1
9064+1
2429-1
262-1
2722-1
2131+1
2330+2
2922-1
10683+1
10662-1
91260-1--
79160-1--
1866-1
1875-1
1846-2*
1898+1
8692-1
8604+1
20261-1
101520-1--
100130-1--
850-1
67090-1--
25681-1
9672-1
9632-1
12453+1
16723+1
3096+1
3004-1
3055+1
4703-1
91410-1--
91450-1--
20073+1
81592+1
95460-1--
10832-1
10883+1
3916-1
3217-1
3127+1
3624+2
3525+1
36312+1
9403+1
96660-1--
5842-1
5886+1
5893-1
3217+2*
94730-1--
94740-1--
94750-1--
22483+1
22401-1
22411-1
22421-1
22433+1
4683-1
4654+1
2836+1
24702+1
85480-1--
32102+1
5674+1
4914-1
4619+1
4416-1
431-3*
4020+1
3473-1
87590-1--
81732+1
24591-1
24512+1
104020-1--
101510-1--
93310-1--
104070-1--
104080-1--
104090-1--
96290-1--
96230-1--
5435+1
84442+1
3694-1
94860-1--
5418+1
5317+1
5215-2
99950-1--
99970-1--
4255+1
4275+1
4264-1
24391-1
93550-1--
101730-1--
101760-1--
49912+1
5293-1
12333+1
19641-1
38042+1
100530-1--
20883+1
91330-1--
91370-1--
10083+1
10042-1
10032-1
21473+1
6015-1
5065+1
5003-1
5014+1
12173+1
6371-1
98160-1--
41520-1--
59032+1
26061-1
100340-1--
90320-1--
81320-1--
29542+1
559+1
66592+1
23824+3*
23861-1
6113-1
87990-1--
14921-1
33342+1
106580-1--
25962+1
25902+1
26251-1
26292+1
73512+1
100110-1--
100170-1--
100160-1--
100150-1--
90570-1--
7744+1
7714+1
7314+1
7016+1
7816+1
10414+1
10463+1
8654+1
8644+1
23241-1
23641-1
23611-1
18633+1
948-1
8932-1
8944+1
17871-1
76062+1
24932+1
24921-1
26492+1
100720-1--
90780-1--
31482+1
16323+1
23422+1
18833+1
1359+1
1348-1
1388-1
172-5*
96800-1--
96830-1--
96850-1--
8912-1
8011-1
8112-1
91920-1--
89940-1--
91950-1--
33692+1
38863+2*
60052+1
9902-1
92790-1--
100510-1--
90990-1--
7394+1
24011-1
85630-1--
12921-1
24991-1
12943+1
1149-1
11111+1
1198-1
11811+2
85590-1--
87740-1--
Family IDGO IDGO term# genes w/ GO ID
1305GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity3/4(17)
265GO:0000166nucleotide binding3/11(42)
1263GO:0016787hydrolase activity1/4(17)
1263GO:0004806triglyceride lipase activity1/4(17)
3497GO:0046872metal ion binding2/2(9)
9546GO:0016787hydrolase activity1/2(4)
9546GO:0008768UDP-sugar diphosphatase activity1/2(4)
218GO:0016020membrane3/13(48)
218GO:0004745retinol dehydrogenase activity2/13(48)
873GO:0005078MAP-kinase scaffold activity1/4(23)
2954GO:0008465glycerate dehydrogenase activity2/2(9)
499GO:0005096GTPase activator activity2/6(29)
468GO:0005319lipid transporter activity4/10(31)
165GO:0003677DNA binding20/24(57)
8782GO:0016020membrane1/2(6)
9632GO:0016020membrane1/1(4)
3345GO:0005509calcium ion binding2/2(9)
490GO:0003950NAD+ ADP-ribosyltransferase activity2/7(30)
490GO:0004842ubiquitin-protein transferase activity1/7(30)
493GO:0002009morphogenesis of an epithelium2/6(29)
493GO:0005509calcium ion binding1/6(29)
493GO:0007154cell communication1/6(29)
24GO:0008233peptidase activity2/54(230)
24GO:0004175endopeptidase activity4/54(230)
24GO:0004222metalloendopeptidase activity16/54(230)
26GO:0005200structural constituent of cytoskeleton54/166(216)
27GO:0000166nucleotide binding15/49(188)
27GO:0000287magnesium ion binding3/49(188)
27GO:0002039p53 binding1/49(188)
27GO:0004674protein serine/threonine kinase activity1/49(188)
27GO:0004672protein kinase activity5/49(188)
1543GO:0003824catalytic activity1/5(16)
2361GO:0046872metal ion binding1/2(12)
23GO:0000287magnesium ion binding2/61(232)
23GO:0004672protein kinase activity17/61(232)
23GO:0000166nucleotide binding18/61(232)
699GO:0000166nucleotide binding2/4(25)
29GO:0001756somitogenesis1/44(182)
29GO:0035064methylated histone binding2/44(182)
29GO:0030332cyclin binding1/44(182)
29GO:0003700transcription factor activity, sequence-specific DNA binding1/44(182)
29GO:0008017microtubule binding4/44(182)
29GO:0003713transcription coactivator activity2/44(182)
29GO:0003431growth plate cartilage chondrocyte development1/44(182)
29GO:0005198structural molecule activity2/44(182)
29GO:0006364rRNA processing1/44(182)
29GO:0019904protein domain specific binding3/44(182)
29GO:0008168methyltransferase activity1/44(182)
29GO:0001895retina homeostasis1/44(182)
29GO:0004842ubiquitin-protein transferase activity3/44(182)
29GO:0044822poly(A) RNA binding1/44(182)
29GO:0008270zinc ion binding2/44(182)
7612GO:0005125cytokine activity2/2(8)
222GO:0005509calcium ion binding3/8(48)
543GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/5(28)
2156GO:0016020membrane1/2(14)
404GO:0003676nucleic acid binding3/7(33)
2248GO:0016020membrane1/3(13)
162GO:0005216ion channel activity1/9(57)
162GO:0006816calcium ion transport1/9(57)
3804GO:0019901protein kinase binding2/2(9)
933GO:0016567protein ubiquitination2/7(22)
933GO:0035556intracellular signal transduction1/7(22)
280GO:0044325ion channel binding1/7(40)
283GO:0006810transport3/10(40)
283GO:0015485cholesterol binding3/10(40)
2240GO:0016020membrane1/4(13)
2241GO:0016787hydrolase activity1/3(13)
1672GO:0008140cAMP response element binding protein binding2/4(16)
1094GO:0005509calcium ion binding2/4(19)
869GO:0043237laminin-1 binding2/7(23)
869GO:0005576extracellular region2/7(23)
1083GO:0003824catalytic activity4/4(19)
739GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity1/6(24)
1158GO:0016798hydrolase activity, acting on glycosyl bonds2/4(18)
2297GO:0016020membrane2/2(13)
967GO:0003993acid phosphatase activity3/6(21)
2468GO:0003676nucleic acid binding1/2(11)
1150GO:0003779actin binding2/2(18)
2703GO:0044822poly(A) RNA binding1/2(10)
121GO:0002091negative regulation of receptor internalization3/17(74)
121GO:0016020membrane1/17(74)
121GO:0060348bone development2/17(74)
121GO:0051965positive regulation of synapse assembly1/17(74)
121GO:0005518collagen binding1/17(74)
121GO:0001530lipopolysaccharide binding1/17(74)
121GO:0001968fibronectin binding1/17(74)
1492GO:0003735structural constituent of ribosome2/5(17)
260GO:0005244voltage-gated ion channel activity3/11(42)
260GO:0004602glutathione peroxidase activity2/11(42)
124GO:0000166nucleotide binding12/14(73)
9078GO:0033617mitochondrial respiratory chain complex IV assembly1/2(6)
126GO:0008146sulfotransferase activity11/19(71)
264GO:0004871signal transducer activity10/12(42)
138GO:0014719skeletal muscle satellite cell activation2/12(64)
138GO:0005509calcium ion binding1/12(64)
9475GO:0008121ubiquinol-cytochrome-c reductase activity3/3(4)
2499GO:0005154epidermal growth factor receptor binding1/2(11)
1068GO:0008270zinc ion binding2/4(19)
1702GO:0004871signal transducer activity4/4(16)
1557GO:0004720protein-lysine 6-oxidase activity1/3(16)
3565GO:0016403dimethylargininase activity1/2(9)
54GO:0000166nucleotide binding20/33(131)
584GO:0004415hyalurononglucosaminidase activity2/7(27)
584GO:0098641cadherin binding involved in cell-cell adhesion2/7(27)
1062GO:0098641cadherin binding involved in cell-cell adhesion1/6(19)
1062GO:0005615extracellular space2/6(19)
53GO:0000975regulatory region DNA binding1/39(133)
53GO:0001972retinoic acid binding1/39(133)
53GO:0000976transcription regulatory region sequence-specific DNA binding1/39(133)
53GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding6/39(133)
53GO:0001046core promoter sequence-specific DNA binding2/39(133)
53GO:0003677DNA binding9/39(133)
53GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding4/39(133)
53GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3/39(133)
1066GO:0003735structural constituent of ribosome1/3(19)
1066GO:0006396RNA processing1/3(19)
2145GO:0004672protein kinase activity1/3(14)
16GO:0003676nucleic acid binding14/69(264)
16GO:0000166nucleotide binding25/69(264)
2415GO:0016020membrane4/5(11)
427GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/7(32)
427GO:0003676nucleic acid binding3/7(32)
860GO:0007165signal transduction1/4(23)
825GO:0005096GTPase activator activity2/6(23)
825GO:0007165signal transduction1/6(23)
825GO:0002011morphogenesis of an epithelial sheet1/6(23)
297GO:0005096GTPase activator activity3/8(39)
294GO:0003677DNA binding3/9(39)
372GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/7(34)
372GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/7(34)
372GO:0000975regulatory region DNA binding2/7(34)
2253GO:0004842ubiquitin-protein transferase activity1/2(13)
2493GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/2(11)
539GO:0003677DNA binding3/8(28)
822GO:0007165signal transduction1/5(23)
9263GO:0000045autophagosome assembly2/2(5)
590GO:0008270zinc ion binding4/7(27)
2492GO:0003824catalytic activity1/2(11)
708GO:0008017microtubule binding3/5(24)
708GO:0005622intracellular1/5(24)
135GO:0000155phosphorelay sensor kinase activity3/15(65)
135GO:0005216ion channel activity1/15(65)
147GO:0019901protein kinase binding1/12(61)
147GO:0016020membrane3/12(61)
147GO:0030220platelet formation1/12(61)
599GO:0006461protein complex assembly2/6(26)
598GO:0007612learning1/7(26)
134GO:0000166nucleotide binding8/14(66)
986GO:0016020membrane2/5(21)
986GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process1/5(21)
8514GO:0019902phosphatase binding1/2(6)
193GO:0003677DNA binding1/14(51)
193GO:0000166nucleotide binding4/14(51)
1088GO:0004721phosphoprotein phosphatase activity1/5(19)
8444GO:0010629negative regulation of gene expression1/1(7)
271GO:0005178integrin binding1/9(41)
271GO:0005509calcium ion binding2/9(41)
271GO:0001968fibronectin binding2/9(41)
271GO:0005006epidermal growth factor-activated receptor activity2/9(41)
273GO:0000975regulatory region DNA binding1/7(41)
273GO:0003677DNA binding4/7(41)
9656GO:0003735structural constituent of ribosome2/2(4)
3148GO:0051082unfolded protein binding2/2(9)
2364GO:0008270zinc ion binding2/2(12)
80GO:0005215transporter activity7/26(103)
52GO:0005242inward rectifier potassium channel activity21/35(134)
119GO:0016787hydrolase activity4/22(75)
119GO:0042043neurexin family protein binding4/22(75)
119GO:0003990acetylcholinesterase activity2/22(75)
119GO:0004771sterol esterase activity1/22(75)
8526GO:0061630ubiquitin protein ligase activity1/2(6)
1233GO:0006464cellular protein modification process1/5(18)
9714GO:0005525GTP binding1/1(4)
9633GO:0003735structural constituent of ribosome2/2(4)
2099GO:0016020membrane3/4(14)
2302GO:0006904vesicle docking involved in exocytosis1/4(13)
894GO:0003676nucleic acid binding2/4(22)
1856GO:0008270zinc ion binding1/2(16)
798GO:0016020membrane1/6(24)
798GO:0005254chloride channel activity1/6(24)
300GO:0008092cytoskeletal protein binding1/7(38)
3GO:0000287magnesium ion binding1/139(535)
3GO:0000166nucleotide binding72/139(535)
3GO:0003779actin binding2/139(535)
3GO:0004713protein tyrosine kinase activity1/139(535)
3GO:0004672protein kinase activity11/139(535)
3GO:0005524ATP binding1/139(535)
918GO:0016020membrane1/4(22)
918GO:0001525angiogenesis1/4(22)
369GO:0008198ferrous iron binding1/6(34)
915GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/5(22)
914GO:0005102receptor binding3/4(22)
170GO:0006955immune response5/24(57)
7737GO:0008455alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity1/2(7)
529GO:0000166nucleotide binding7/7(28)
1012GO:0003713transcription coactivator activity1/3(20)
1012GO:0000398mRNA splicing, via spliceosome1/3(20)
426GO:0008270zinc ion binding1/6(32)
309GO:0016020membrane1/7(38)
309GO:0005086ARF guanyl-nucleotide exchange factor activity2/7(38)
2769GO:0006810transport1/2(10)
2760GO:0005509calcium ion binding1/2(10)
425GO:0008375acetylglucosaminyltransferase activity3/5(32)
425GO:0015020glucuronosyltransferase activity1/5(32)
9150GO:0016020membrane2/2(5)
581GO:0051497negative regulation of stress fiber assembly1/7(27)
581GO:0045202synapse3/7(27)
1133GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3/4(18)
1130GO:0016020membrane2/4(18)
446GO:0005089Rho guanyl-nucleotide exchange factor activity1/4(32)
2765GO:0000166nucleotide binding1/2(10)
305GO:0015020glucuronosyltransferase activity1/17(38)
381GO:0000166nucleotide binding2/5(33)
382GO:0000831inositol hexakisphosphate 6-kinase activity1/9(33)
382GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity4/9(33)
6005GO:0004108citrate (Si)-synthase activity1/1(8)
9002GO:0016020membrane1/2(6)
243GO:0005509calcium ion binding1/9(44)
243GO:0019899enzyme binding1/9(44)
243GO:0002175protein localization to paranode region of axon1/9(44)
102GO:0007155cell adhesion3/18(88)
102GO:0070062extracellular exosome2/18(88)
102GO:0007224smoothened signaling pathway2/18(88)
229GO:0005216ion channel activity4/13(47)
589GO:0015018galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity4/7(27)
106GO:0003676nucleic acid binding2/18(84)
106GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/18(84)
106GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/18(84)
106GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding1/18(84)
106GO:0001046core promoter sequence-specific DNA binding3/18(84)
827GO:0000386second spliceosomal transesterification activity1/2(23)
105GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/26(85)
105GO:0003677DNA binding16/26(85)
39GO:0001948glycoprotein binding2/43(155)
39GO:0005198structural molecule activity14/43(155)
1387GO:0005524ATP binding3/4(17)
1432GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/3(17)
292GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding4/8(39)
292GO:0003676nucleic acid binding1/8(39)
31GO:0004252serine-type endopeptidase activity2/24(171)
31GO:0001964startle response2/24(171)
31GO:0016020membrane2/24(171)
31GO:0008344adult locomotory behavior2/24(171)
31GO:0003682chromatin binding1/24(171)
2572GO:0010181FMN binding1/2(10)
21GO:0001221transcription cofactor binding1/62(240)
21GO:0001046core promoter sequence-specific DNA binding2/62(240)
21GO:0000166nucleotide binding1/62(240)
21GO:0001105RNA polymerase II transcription coactivator activity2/62(240)
21GO:0003676nucleic acid binding5/62(240)
21GO:0003677DNA binding6/62(240)
21GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3/62(240)
21GO:0003682chromatin binding3/62(240)
21GO:0005524ATP binding12/62(240)
1126GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding2/4(18)
9398GO:0003735structural constituent of ribosome1/2(5)
1632GO:0006810transport1/4(16)
1632GO:0008526phosphatidylinositol transporter activity1/4(16)
35GO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding2/37(166)
35GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding6/37(166)
35GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/37(166)
35GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding1/37(166)
35GO:0003677DNA binding3/37(166)
1245GO:0016491oxidoreductase activity2/2(17)
2379GO:0004046aminoacylase activity2/4(12)
2379GO:0016020membrane1/4(12)
990GO:0048706embryonic skeletal system development1/5(21)
2676GO:0002053positive regulation of mesenchymal cell proliferation1/2(10)
114GO:0004620phospholipase activity8/22(79)
40GO:0003924GTPase activity9/40(152)
40GO:0004871signal transducer activity3/40(152)
40GO:0005525GTP binding19/40(152)
1004GO:0008270zinc ion binding1/3(20)
1003GO:0003779actin binding1/4(20)
1003GO:0030018Z disc1/4(20)
963GO:0003690double-stranded DNA binding2/5(21)
963GO:0003677DNA binding1/5(21)
2162GO:0003723RNA binding3/3(14)
637GO:0004888transmembrane signaling receptor activity4/9(25)
637GO:0005149interleukin-1 receptor binding2/9(25)
637GO:0019843rRNA binding1/9(25)
1164GO:0008270zinc ion binding1/5(18)
44GO:0004497monooxygenase activity26/47(148)
44GO:0005506iron ion binding2/47(148)
2459GO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity2/2(11)
338GO:0016491oxidoreductase activity2/10(35)
338GO:0004362glutathione-disulfide reductase activity1/10(35)
338GO:0004791thioredoxin-disulfide reductase activity5/10(35)
9126GO:0005184neuropeptide hormone activity1/2(5)
624GO:0046983protein dimerization activity2/6(26)
624GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/6(26)
8210GO:0055085transmembrane transport2/2(7)
570GO:0008270zinc ion binding3/6(27)
454GO:0005198structural molecule activity5/7(31)
455GO:0004871signal transducer activity2/5(31)
2294GO:0005159insulin-like growth factor receptor binding1/4(13)
2294GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway2/4(13)
60GO:0005737cytoplasm1/27(120)
60GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/27(120)
60GO:0005200structural constituent of cytoskeleton1/27(120)
60GO:0005524ATP binding1/27(120)
60GO:0000166nucleotide binding9/27(120)
9639GO:0004129cytochrome-c oxidase activity2/2(4)
258GO:0000166nucleotide binding3/8(42)
89GO:0000166nucleotide binding9/18(97)
2196GO:0003682chromatin binding2/3(13)
252GO:0019992diacylglycerol binding4/7(42)
252GO:0030742GTP-dependent protein binding1/7(42)
2730GO:0005102receptor binding1/2(10)
175GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/9(56)
175GO:0003677DNA binding2/9(56)
251GO:0009922fatty acid elongase activity3/11(43)
251GO:0001104RNA polymerase II transcription cofactor activity2/11(43)
251GO:0016740transferase activity2/11(43)
9635GO:0005783endoplasmic reticulum2/2(4)
347GO:0000166nucleotide binding4/7(35)
255GO:0004497monooxygenase activity3/9(42)
2051GO:0003723RNA binding2/5(15)
1423GO:0000166nucleotide binding4/4(17)
3210GO:0016020membrane1/2(9)
2054GO:0003824catalytic activity1/2(15)
8994GO:0005737cytoplasm2/2(6)
978GO:0016407acetyltransferase activity2/5(21)
978GO:0004596peptide alpha-N-acetyltransferase activity1/5(21)
2770GO:0008237metallopeptidase activity2/3(10)
2GO:0000166nucleotide binding33/155(642)
2GO:0003924GTPase activity35/155(642)
2GO:0005509calcium ion binding2/155(642)
2GO:0005525GTP binding32/155(642)
186GO:0005216ion channel activity11/13(52)
1796GO:0003677DNA binding2/2(16)
184GO:0000226microtubule cytoskeleton organization1/6(55)
6GO:0005200structural constituent of cytoskeleton1/103(437)
6GO:1990126retrograde transport, endosome to plasma membrane2/103(437)
6GO:0007165signal transduction2/103(437)
6GO:0003676nucleic acid binding2/103(437)
6GO:0003950NAD+ ADP-ribosyltransferase activity2/103(437)
6GO:0035556intracellular signal transduction1/103(437)
6GO:0000122negative regulation of transcription from RNA polymerase II promoter1/103(437)
6GO:0000149SNARE binding1/103(437)
6GO:0019887protein kinase regulator activity1/103(437)
6GO:0004672protein kinase activity2/103(437)
6GO:0008134transcription factor binding2/103(437)
6GO:0090090negative regulation of canonical Wnt signaling pathway3/103(437)
6GO:0044212transcription regulatory region DNA binding1/103(437)
6GO:0005216ion channel activity2/103(437)
6GO:0017137Rab GTPase binding1/103(437)
6GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity2/103(437)
6GO:0045893positive regulation of transcription, DNA-templated2/103(437)
6GO:0007520myoblast fusion2/103(437)
6GO:0001085RNA polymerase II transcription factor binding2/103(437)
6GO:0010613positive regulation of cardiac muscle hypertrophy1/103(437)
6GO:0008093cytoskeletal adaptor activity1/103(437)
6GO:0016567protein ubiquitination3/103(437)
6GO:0005634nucleus2/103(437)
2110GO:0003677DNA binding2/4(14)
1217GO:0019900kinase binding2/4(18)
189GO:0004407histone deacetylase activity1/8(51)
189GO:0001025RNA polymerase III transcription factor binding1/8(51)
1037GO:0016301kinase activity3/6(20)
500GO:0004871signal transducer activity5/7(29)
4GO:0001948glycoprotein binding1/119(497)
4GO:0004252serine-type endopeptidase activity50/119(497)
4GO:0004175endopeptidase activity2/119(497)
3878GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/2(9)
3879GO:0004864protein phosphatase inhibitor activity2/2(9)
1211GO:0008381mechanically-gated ion channel activity1/4(18)
9137GO:0003714transcription corepressor activity1/2(5)
906GO:0005509calcium ion binding3/4(22)
10407GO:0000166nucleotide binding1/1(2)
465GO:0006355regulation of transcription, DNA-templated1/10(31)
465GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/10(31)
465GO:0003677DNA binding1/10(31)
9138GO:0004483mRNA (nucleoside-2'-O-)-methyltransferase activity1/2(5)
9505GO:0019899enzyme binding1/2(4)
2735GO:0051225spindle assembly1/2(10)
506GO:0010506regulation of autophagy2/6(29)
111GO:0005201extracellular matrix structural constituent1/21(82)
111GO:0005615extracellular space3/21(82)
111GO:0044822poly(A) RNA binding1/21(82)
111GO:0031012extracellular matrix2/21(82)
111GO:0002020protease binding1/21(82)
111GO:0035987endodermal cell differentiation2/21(82)
787GO:0005216ion channel activity1/6(24)
787GO:0005516calmodulin binding2/6(24)
2186GO:0090002establishment of protein localization to plasma membrane2/3(14)
2185GO:0004812aminoacyl-tRNA ligase activity2/4(14)
8GO:0003774motor activity3/108(417)
8GO:0007165signal transduction1/108(417)
8GO:0000146microfilament motor activity8/108(417)
8GO:0000166nucleotide binding38/108(417)
9623GO:0005654nucleoplasm1/1(4)
90GO:0005198structural molecule activity18/37(97)
10011GO:0005739mitochondrion2/2(3)
3631GO:0003677DNA binding1/2(9)
95GO:0004842ubiquitin-protein transferase activity1/21(95)
95GO:0008270zinc ion binding5/21(95)
161GO:0003824catalytic activity1/10(57)
161GO:0007165signal transduction1/10(57)
161GO:0042803protein homodimerization activity2/10(57)
97GO:0003958NADPH-hemoprotein reductase activity3/19(91)
97GO:0005272sodium channel activity3/19(91)
97GO:0005261cation channel activity1/19(91)
97GO:0004517nitric-oxide synthase activity3/19(91)
11GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9/99(347)
11GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/99(347)
11GO:0000976transcription regulatory region sequence-specific DNA binding1/99(347)
11GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding3/99(347)
11GO:0003677DNA binding30/99(347)
10GO:0005509calcium ion binding34/114(380)
8513GO:0005096GTPase activator activity1/2(6)
12GO:0004930G-protein coupled receptor activity6/93(341)
12GO:0004871signal transducer activity51/93(341)
12GO:0001626nociceptin receptor activity2/93(341)
12GO:0001596angiotensin type I receptor activity2/93(341)
12GO:0003779actin binding2/93(341)
12GO:0001965G-protein alpha-subunit binding1/93(341)
12GO:0002020protease binding2/93(341)
1021GO:0003676nucleic acid binding2/2(20)
36GO:0005112Notch binding10/30(160)
36GO:0001047core promoter binding1/30(160)
36GO:0005509calcium ion binding5/30(160)
392GO:0003779actin binding2/9(33)
18GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs2/66(256)
18GO:0004930G-protein coupled receptor activity1/66(256)
18GO:0001594trace-amine receptor activity1/66(256)
18GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/Go4/66(256)
18GO:0001587Gq/11-coupled serotonin receptor activity2/66(256)
18GO:0001965G-protein alpha-subunit binding2/66(256)
18GO:0004871signal transducer activity28/66(256)
1282GO:0001102RNA polymerase II activating transcription factor binding2/4(17)
865GO:0005506iron ion binding2/4(23)
864GO:0007275multicellular organism development2/4(23)
864GO:0001736establishment of planar polarity2/4(23)
1104GO:0016740transferase activity2/4(19)
1104GO:0015020glucuronosyltransferase activity1/4(19)
390GO:0019900kinase binding4/9(33)
390GO:0003713transcription coactivator activity1/9(33)
2242GO:0000062fatty-acyl-CoA binding2/4(13)
32GO:0002020protease binding1/58(170)
32GO:0016525negative regulation of angiogenesis2/58(170)
32GO:0005615extracellular space19/58(170)
32GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling1/58(170)
32GO:0004867serine-type endopeptidase inhibitor activity8/58(170)
8580GO:0003676nucleic acid binding1/2(6)
3334GO:0005737cytoplasm2/2(9)
501GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/9(29)
501GO:0003677DNA binding6/9(29)
774GO:0015909long-chain fatty acid transport2/4(24)
10368GO:0009116nucleoside metabolic process1/1(2)
883GO:0030534adult behavior1/4(23)
568GO:0005246calcium channel regulator activity1/5(27)
9342GO:0001601peptide YY receptor activity2/3(5)
559GO:0046983protein dimerization activity3/7(27)
559GO:0000976transcription regulatory region sequence-specific DNA binding1/7(27)
559GO:0001102RNA polymerase II activating transcription factor binding1/7(27)
2866GO:0016020membrane1/2(9)
8177GO:0005737cytoplasm2/2(7)
2634GO:0008168methyltransferase activity2/2(10)
556GO:0044822poly(A) RNA binding1/4(27)
1169GO:0000976transcription regulatory region sequence-specific DNA binding1/4(18)
1169GO:0003713transcription coactivator activity1/4(18)
10658GO:0004045aminoacyl-tRNA hydrolase activity1/1(2)
552GO:0001047core promoter binding1/6(28)
2439GO:0042803protein homodimerization activity1/2(11)
118GO:0016301kinase activity8/20(77)
118GO:0046854phosphatidylinositol phosphorylation1/20(77)
118GO:0000166nucleotide binding2/20(77)
1292GO:0004842ubiquitin-protein transferase activity1/4(17)
9752GO:0001664G-protein coupled receptor binding2/2(3)
2949GO:0004843thiol-dependent ubiquitin-specific protease activity2/2(9)
234GO:0003677DNA binding4/11(46)
237GO:0016740transferase activity2/15(45)
237GO:0004307ethanolaminephosphotransferase activity1/15(45)
230GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/10(47)
230GO:0000979RNA polymerase II core promoter sequence-specific DNA binding2/10(47)
230GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/10(47)
230GO:0001047core promoter binding1/10(47)
1891GO:0016020membrane3/3(16)
9160GO:0008137NADH dehydrogenase (ubiquinone) activity1/2(5)
233GO:0005178integrin binding1/10(46)
233GO:0005201extracellular matrix structural constituent1/10(46)
3438GO:0032947protein complex scaffold2/2(9)
1051GO:0005267potassium channel activity2/5(20)
1051GO:0005249voltage-gated potassium channel activity2/5(20)
81GO:0003779actin binding1/27(102)
81GO:0005856cytoskeleton4/27(102)
81GO:0010592positive regulation of lamellipodium assembly1/27(102)
81GO:0004721phosphoprotein phosphatase activity2/27(102)
81GO:0008092cytoskeletal protein binding2/27(102)
893GO:0003824catalytic activity5/6(22)
878GO:0005615extracellular space1/7(23)
878GO:0004866endopeptidase inhibitor activity5/7(23)
49GO:0003777microtubule motor activity11/30(138)
951GO:0004842ubiquitin-protein transferase activity2/4(21)
951GO:0008270zinc ion binding1/4(21)
1193GO:0004843thiol-dependent ubiquitin-specific protease activity1/3(18)
875GO:0002244hematopoietic progenitor cell differentiation1/4(23)
954GO:0016020membrane1/4(21)
870GO:0000166nucleotide binding3/6(23)
956GO:0050770regulation of axonogenesis2/5(21)
1GO:0001223transcription coactivator binding2/267(729)
1GO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding3/267(729)
1GO:0000976transcription regulatory region sequence-specific DNA binding1/267(729)
1GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding6/267(729)
1GO:0003676nucleic acid binding66/267(729)
1GO:0001046core promoter sequence-specific DNA binding1/267(729)
1GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9/267(729)
1GO:0001078transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding2/267(729)
1GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/267(729)
321GO:0017112Rab guanyl-nucleotide exchange factor activity4/9(37)
5GO:0000287magnesium ion binding2/130(478)
5GO:0000166nucleotide binding70/130(478)
5GO:0004674protein serine/threonine kinase activity1/130(478)
5GO:0004672protein kinase activity10/130(478)
5GO:0046872metal ion binding1/130(478)
5GO:0002039p53 binding2/130(478)
1117GO:0008053mitochondrial fusion2/6(19)
1117GO:0042803protein homodimerization activity2/6(19)
9GO:0007626locomotory behavior1/100(386)
9GO:0000070mitotic sister chromatid segregation1/100(386)
9GO:0000902cell morphogenesis2/100(386)
9GO:0005783endoplasmic reticulum1/100(386)
9GO:0006355regulation of transcription, DNA-templated2/100(386)
9GO:0002467germinal center formation2/100(386)
9GO:0051015actin filament binding1/100(386)
9GO:0003779actin binding6/100(386)
9GO:0016567protein ubiquitination8/100(386)
9GO:2001243negative regulation of intrinsic apoptotic signaling pathway1/100(386)
9GO:0007010cytoskeleton organization1/100(386)
9GO:0031397negative regulation of protein ubiquitination2/100(386)
9GO:2000312regulation of kainate selective glutamate receptor activity2/100(386)
9GO:0004842ubiquitin-protein transferase activity4/100(386)
9GO:0006446regulation of translational initiation3/100(386)
9GO:0042802identical protein binding3/100(386)
9GO:0005615extracellular space2/100(386)
3079GO:0004222metalloendopeptidase activity1/1(9)
1294GO:0008270zinc ion binding2/4(17)
201GO:0001104RNA polymerase II transcription cofactor activity1/13(50)
201GO:0005215transporter activity9/13(50)
1050GO:0015269calcium-activated potassium channel activity3/4(20)
203GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/14(49)
203GO:0000976transcription regulatory region sequence-specific DNA binding3/14(49)
203GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding1/14(49)
203GO:0006366transcription from RNA polymerase II promoter1/14(49)
2629GO:0000132establishment of mitotic spindle orientation1/2(10)
142GO:0000166nucleotide binding6/13(63)
10194GO:0019079viral genome replication1/1(2)
140GO:0000150recombinase activity1/6(64)
140GO:0000166nucleotide binding2/6(64)
2401GO:0004871signal transducer activity1/2(12)
611GO:0004842ubiquitin-protein transferase activity3/5(26)
2386GO:0005185neurohypophyseal hormone activity3/4(12)
615GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/6(26)
77GO:0004675transmembrane receptor protein serine/threonine kinase activity1/26(103)
77GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding1/26(103)
77GO:0000166nucleotide binding20/26(103)
8799GO:0005739mitochondrion2/2(6)
831GO:0004668protein-arginine deiminase activity1/4(23)
73GO:0004222metalloendopeptidase activity8/26(108)
5204GO:0016020membrane1/1(8)
70GO:0004871signal transducer activity15/23(109)
567GO:0005102receptor binding4/7(27)
567GO:0008083growth factor activity1/7(27)
78GO:0005216ion channel activity2/14(103)
78GO:0005245voltage-gated calcium channel activity1/14(103)
1041GO:0001786phosphatidylserine binding2/4(20)
1046GO:0005634nucleus1/6(20)
1046GO:0016020membrane3/6(20)
1046GO:0005783endoplasmic reticulum1/6(20)
262GO:0003700transcription factor activity, sequence-specific DNA binding1/11(42)
262GO:0001076transcription factor activity, RNA polymerase II transcription factor binding2/11(42)
262GO:0000979RNA polymerase II core promoter sequence-specific DNA binding3/11(42)
262GO:0000976transcription regulatory region sequence-specific DNA binding2/11(42)
262GO:0001158enhancer sequence-specific DNA binding1/11(42)
705GO:0005085guanyl-nucleotide exchange factor activity1/6(25)
2342GO:0015187glycine transmembrane transporter activity2/4(12)
2234GO:0004872receptor activity1/3(13)
940GO:0004871signal transducer activity3/11(22)
46GO:0004435phosphatidylinositol phospholipase C activity14/34(146)
46GO:0001786phosphatidylserine binding2/34(146)
9032GO:0008565protein transporter activity1/2(6)
353GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/8(34)
353GO:0003677DNA binding1/8(34)
2007GO:0016020membrane1/2(15)
8647GO:0005216ion channel activity2/2(6)
516GO:0000287magnesium ion binding2/5(29)
516GO:0004672protein kinase activity1/5(29)
7466GO:0005604basement membrane2/2(8)
187GO:0005201extracellular matrix structural constituent2/12(52)
169GO:0009897external side of plasma membrane1/18(57)
169GO:0016020membrane5/18(57)
169GO:0043274phospholipase binding2/18(57)
169GO:0005518collagen binding1/18(57)