Node summary

Genes17023
Ancestral nodeBOP11

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CAFE summary

Expansions513 (16 rapid)
Contractions338 (2 rapid)
Extinctions192

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Family IDGene CountChangeRapid (*)?Exctinction (--)?
59802+1
2746+1
2797+2
92530-1--
35102+1
26892+1
26803+2*
9913+1
9010-1
9515+3
948-1
11733+1
8765+1
8772-1
8752-1
8702-1
8712-1
6252-1
20391-1
3933-1
3923-1
3965+1
3945+1
23011-1
58400-1--
37462+1
37432+1
37412+1
1726-1
103960-1--
62180-1--
97520-1--
97580-1--
88480-1--
76670-1--
17603+1
17663+1
6992-1
2527+1
2516+1
2567+2
95090-1--
95030-1--
95050-1--
25162+1
25121-1
101820-1--
101890-1--
11593+1
85200-1--
13243+1
21863+1
1518+1
1559+1
15710+3
27232+1
27222+1
27282+1
91990-1--
91980-1--
97770-1--
97700-1--
8132-1
8145+2
8172-1
17073+1
30272+1
87380-1--
2397+1
2377+2
2307+1
2315-1
25332+1
9384+1
95660-1--
9322-1
9312-1
9352-1
93980-1--
7954+1
93880-1--
7991-1
21441-1
24153+1
11393+1
21411-1
11313+1
11353+1
80500-1--
28832+1
28862+1
28892+1
19264+2*
19271-1
27062+1
24110-1--
85400-1--
17283+1
17213+1
79332+1
30012+1
30002+1
94540-1--
32872+1
2165-1
2184-2
36412+1
25520-1--
25532+1
25552+1
25573+2
9102-1
6304+1
80732+1
12113+1
6344+1
11134+2*
14403+1
14481-1
82640-1--
1968+1
1915-1
1905-1
27622+1
27662+1
79032+1
97390-1--
653-2
30652+1
13081-1
4985+1
4905+1
25742+1
25722+1
25732+1
35922+1
9732-1
9792-1
33852+1
14651-1
14673+1
3183-1
22941-1
86950-1--
86970-1--
86930-1--
86920-1--
55782+1
27423+2
27442+1
27473+2
27482+1
20381-1
30412+1
10943+1
10974+2
77342+1
36042+1
9514+1
9564+1
96740-1--
96760-1--
96770-1--
96710-1--
96780-1--
89000-1--
5974+1
5994+1
28290-1--
14053+1
15401-1
32632+1
3395+1
3306+1
94470-1--
94460-1--
94440-1--
91150-1--
91140-1--
94410-1--
94400-1--
34102+1
85330-1--
20143+1
90350-1--
4585+1
4516+2
4555+1
7524+1
40022+1
39730-1--
44712+1
24653+1
24602+1
96530-1--
96500-1--
96560-1--
96570-1--
93030-1--
5784+1
5715+2
5705+1
28022+1
28052+1
14273+1
3525+1
3514-1
20781-1
97930-1--
84100-1--
98080-1--
31972+1
2947+2
2906+1
24492+1
104110-1--
96390-1--
93220-1--
96330-1--
96350-1--
14373+1
14323+1
14333+1
28622+1
28632+1
5566+2
5525+1
11903+1
13483+1
38312+1
13443+1
3735+1
61460-1--
22771-1
20511-1
20543+1
20591-1
94092+1
88580-1--
4135+1
13853+1
13871-1
4183-1
81070-1--
24242+1
78402+1
93420-1--
93470-1--
93480-1--
18181-1
19703+1
28422+1
28432+1
19083+1
38192+1
94280-1--
94202+1
76154+3*
10164+1
10124+1
4345+1
4313-1
14361-1
37952+1
24001-1
24083+2
32422+1
32472+1
32452+1
19901-1
33072+1
106110-1--
19923+1
6104+1
20601-1
6142-1
6155+1
20633+1
20641-1
5182-2
5135+1
5125+1
5172-1
12274+2
12261-1
12213+1
12201-1
6285+2
38792+1
38722+1
38732+1
84790-1--
84760-1--
75662+1
22361-1
20951-1
20941-1
367+1
90090-1--
86680-1--
57282+1
78050-1--
78090-1--
23962+1
21731-1
19321-1
19301-1
19351-1
19383+1
103770-1--
6055+2
6044+1
12073+1
75802+1
75832+1
45562+1
26152+1
26182+1
100260-1--
100250-1--
11863+1
53502+1
10593+1
11805+2
17021-1
21370-2--
752-2
21343+1
21353+1
23742+1
19193+1
8831-1
8862-1
100190-1--
98890-1--
12683+1
19113+1
19103+1
76100-1--
59780-1--
25852+1
25802+1
100060-1--
26382+1
100030-1--
95960-1--
92220-1--
95920-1--
35402+1
29632+1
7625+2
76011+8*
7642-1
10757+5*
31372+1
31362+1
10423+1
23592+1
23511-1
37392+1
37372+1
37312+1
27870-1--
100210-1--
12673+1
94690-1--
76350-1--
98430-1--
6484+1
38920-1--
38902+1
26582+1
26512+1
26562+1
26552+1
90680-1--
35642+1
30342+1
14710+2
7014+1
7024+1
24862+1
19873+1
12601-1
24822+1
14593+1
85740-1--
37172+1
81880-1--
12011+1
12210+1
12310+1
12411+1
12610+1
12710+1
33722+1
88130-1--
104030-1--
82160-1--
95690-1--
15173+1
15103+1
88990-1--
33962+1
2676+1
2653-2
2646+1
9814+1
9842-1
35082+1
26782+1
29232+1
29262+1
7231-2*
11653+1
11613+1
11634+2
20351-1
4735+1
20333+1
85550-1--
27843+2
80070-1--
23160-1--
37742+1
37782+1
10811+1
10210-1
10115+3
10613+1
1047-1
10513+2
100000-1--
100010-1--
97450-1--
88350-1--
6892-1
85022+1
2447+1
2467+1
2437+1
95310-1--
92460-1--
36922+1
36952+1
35232+1
26972+1
21521-1
21531-1
11414+2
11483+1
7684+1
3833-1
3895+1
10764+1
10773+1
10743+1
37502+1
21910-1--
21951-1
16111+3*
1636-1
27362+1
27332+1
27382+1
91870-1--
91840-1--
103680-1--
103620-1--
97600-1--
8072-1
8062-1
8054+1
17783+1
15571-1
15583+1
2295-1
2257+1
2247+1
2228+1
25000-1--
12563+1
101940-1--
101990-1--
11253+1
103540-1--
27052+1
27042+1
27073+2
1445-1
1436-2
14010+1
27012+1
1499+1
27102+1
27143+2
27182+1
27192+1
33472+1
8252-1
1048+2
1332-6*
1243+1
1539+1
1732-1
1630-2
1933+1
1833+1
81820-1--
2049+2
2075-1
2098+1
93820-1--
36592+1
25252+1
9201-1
23574+3*
13713+1
71592+1
13733+1
93970-1--
4015+1
86030-1--
28932+1
28922+1
18953+1
18963+1
26682+1
466+2
27722+1
8444+1
8424+1
8412-1
24072+1
4805+1
67232+1
56552+1
36782+1
36710-1--
36742+1
25452+1
14563+1
9071-2
9092-1
14713+1
14743+1
14781-1
42232+1
2527-1
265-1
2032+2
2132+2
2232+2
2826+2
2920-3
10683+1
10653+1
10643+1
10665+2
22813+2*
91220-1--
82310-1--
79172+1
1836-1
1818+1
1879+2
34412+1
20223+1
101520-1--
104040-1--
30552+1
851-1
13133+1
77292+1
77252+1
67092+1
25602+1
25662+1
9672-1
9604+2*
9612-1
9634+1
9694+1
12453+1
6495+2
89190-1--
16741-1
16764+2*
14141-1
3096+1
3007+2
3016+1
4702-2
91022+1
91000-1--
91450-1--
81590-1--
95460-1--
95440-1--
10844+2
10883+1
4495+1
3921+1
3819-1
77012+1
3322+1
3218-1
3120-1
3027+3
3623+2
3524+1
3419-1
34692+1
9491-1
9472-1
9452-1
9401-1
9414+1
24102+1
63270-1--
5847+4*
28352+1
14393+1
21263+1
3256+1
30732+1
94730-1--
94750-1--
22480-1--
22401-1
100692+1
92090-1--
27992+1
27952+1
4683-1
4663-1
13573+1
13543+1
83692+1
31852+1
31872+1
31822+1
2886+1
14443+1
2858+3
24742+1
76950-1--
29062+1
19853+1
28172+1
5605+1
5664+1
4619+1
4416-1
4519+1
4217-1
4311+4*
3465+1
3475+1
3405+1
3493-1
94380-1--
94390-1--
94340-1--
20471-1
4065+1
4055+1
40320-1--
81730-1--
81740-1--
93350-1--
104020-1--
101510-1--
6504+1
104070-1--
104080-1--
104090-1--
92900-1--
96230-1--
28792+1
5462-2
5443-1
76850-1--
38202+1
84440-1--
84420-1--
3625+1
22021-1
22031-1
22061-1
79912+1
94360-1--
29992+1
5817+2
5518+1
5418+1
5617+1
5119+1
5314-2
5219+2
29922+1
4285+1
13993+1
13984+2
4255+1
23323+2
24362+1
78320-1--
63432+1
93500-1--
101730-1--
101760-1--
28592+1
13963+1
5285+1
12371-1
24882+1
65052+1
41782+1
22291-1
91370-1--
91360-1--
10092-1
91340-1--
86120-1--
92710-1--
92740-1--
26672+1
93780-1--
18253+1
19211-1
19293+1
6117+2
6317+1
6415+1
6516+1
6618+2
6718+2
6815+1
6915+1
5095+1
5032-1
12163+1
6384+1
12183+1
38672+1
41522+1
26042+1
26052+1
26032+1
26082+1
90300-1--
7534+1
7564+1
29512+1
31062+1
560+1
86750-1--
23831-1
23872+1
14903+1
33320-1--
14923+1
106580-1--
35952+1
91290-1--
38472+1
10733+1
25952+1
25932+1
10701-1
26222+1
26232+1
26272+1
100110-1--
100170-1--
100160-1--
100142+1
7617+2
7515+1
7415+1
29702+1
29712+1
7912-1
7820+5*
10482-1
27502+1
20233+1
23684+2
18633+1
21063+1
21043+1
949+1
8953+1
8964+1
17873+1
6784+1
76060-1--
76052+1
76042+1
76012+1
24902+1
24933+2
41162+1
26482+1
90740-1--
90710-1--
29112+1
29122+1
7134+1
7125+2
31452+1
35022+1
35032+1
35042+1
35072+1
21201-1
21221-1
13111+2
13011+2
1379+1
1359+1
13810+1
96820-1--
96840-1--
8918+5*
8114+1
88040-1--
76230-1--
91930-1--
38852+1
38862+1
38892+1
73992+1
90990-1--
90942+1
90910-1--
90930-1--
29352+1
18391-1
31662+1
7364+1
12743+1
23253+2*
12923+1
1149-1
11111+1
11011+1
1198-1
1188-1
84842+1
Family IDGO IDGO term# genes w/ GO ID
6723GO:0003824catalytic activity1/2(8)
1141GO:0005113patched binding2/5(18)
1141GO:0005119smoothened binding1/5(18)
428GO:0004725protein tyrosine phosphatase activity1/7(32)
428GO:0000975regulatory region DNA binding4/7(32)
346GO:0003700transcription factor activity, sequence-specific DNA binding1/8(35)
346GO:0046983protein dimerization activity1/8(35)
346GO:0003677DNA binding1/8(35)
346GO:0001046core promoter sequence-specific DNA binding1/8(35)
347GO:0000166nucleotide binding4/7(35)
340GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding3/8(35)
813GO:0019901protein kinase binding2/6(24)
813GO:0004672protein kinase activity1/6(24)
814GO:0043515kinetochore binding1/5(23)
814GO:0002162dystroglycan binding1/5(23)
349GO:0000166nucleotide binding5/8(34)
817GO:0043395heparan sulfate proteoglycan binding1/6(23)
2911GO:0010764negative regulation of fibroblast migration1/2(9)
7604GO:0005739mitochondrion2/2(8)
713GO:0005654nucleoplasm2/6(24)
713GO:0031867EP4 subtype prostaglandin E2 receptor binding1/6(24)
713GO:0004842ubiquitin-protein transferase activity1/6(24)
712GO:0005249voltage-gated potassium channel activity2/5(24)
1490GO:0003824catalytic activity4/4(17)
1492GO:0003735structural constituent of ribosome2/5(17)
1068GO:0008270zinc ion binding2/4(19)
1702GO:0004871signal transducer activity4/4(16)
1707GO:0003700transcription factor activity, sequence-specific DNA binding1/3(16)
1065GO:0003677DNA binding1/6(19)
1064GO:0005200structural constituent of cytoskeleton1/7(19)
1066GO:0003735structural constituent of ribosome1/3(19)
1066GO:0006396RNA processing1/3(19)
294GO:0003677DNA binding3/9(39)
290GO:0030234enzyme regulator activity2/9(39)
290GO:0003723RNA binding1/9(39)
1084GO:0003677DNA binding1/5(19)
1084GO:0001046core promoter sequence-specific DNA binding2/5(19)
597GO:0005856cytoskeleton1/7(26)
597GO:0005198structural molecule activity3/7(26)
3774GO:0005179hormone activity1/1(9)
599GO:0006461protein complex assembly2/6(26)
8603GO:0005739mitochondrion2/2(6)
191GO:0005178integrin binding1/14(51)
191GO:0005201extracellular matrix structural constituent5/14(51)
190GO:0005125cytokine activity3/13(51)
190GO:0008009chemokine activity4/13(51)
1088GO:0004721phosphoprotein phosphatase activity1/5(19)
3678GO:0051020GTPase binding2/2(9)
274GO:0004062aryl sulfotransferase activity2/12(41)
274GO:0004027alcohol sulfotransferase activity1/12(41)
274GO:0008146sulfotransferase activity5/12(41)
3145GO:0005484SNAP receptor activity3/3(9)
4556GO:0000166nucleotide binding1/1(8)
279GO:0015031protein transport5/9(40)
279GO:0006887exocytosis2/9(40)
3674GO:0043130ubiquitin binding2/2(9)
3385GO:0005501retinoid binding2/2(9)
3027GO:0004605phosphatidate cytidylyltransferase activity2/2(9)
7991GO:0016042lipid catabolic process1/1(7)
9137GO:0003714transcription corepressor activity1/2(5)
7635GO:0003839gamma-glutamylcyclotransferase activity1/2(7)
2383GO:0008508bile acid:sodium symporter activity3/4(12)
2387GO:0006914autophagy2/4(12)
528GO:0005044scavenger receptor activity1/5(28)
528GO:0003682chromatin binding1/5(28)
1012GO:0003713transcription coactivator activity1/3(20)
1012GO:0000398mRNA splicing, via spliceosome1/3(20)
449GO:0007165signal transduction2/6(31)
449GO:0031699beta-3 adrenergic receptor binding2/6(31)
2762GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/3(10)
2449GO:0004871signal transducer activity1/2(11)
2766GO:0042802identical protein binding1/3(10)
108GO:0005178integrin binding2/23(83)
108GO:0004859phospholipase inhibitor activity4/23(83)
108GO:0005509calcium ion binding12/23(83)
108GO:0002020protease binding1/23(83)
102GO:0007155cell adhesion3/18(88)
102GO:0070062extracellular exosome2/18(88)
102GO:0007224smoothened signaling pathway2/18(88)
101GO:0016020membrane2/23(89)
106GO:0003676nucleic acid binding2/18(84)
106GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/18(84)
106GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/18(84)
106GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding1/18(84)
106GO:0001046core promoter sequence-specific DNA binding3/18(84)
104GO:0004930G-protein coupled receptor activity2/28(87)
104GO:0004871signal transducer activity3/28(87)
105GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/26(85)
105GO:0003677DNA binding16/26(85)
2047GO:0004047aminomethyltransferase activity1/4(15)
39GO:0001948glycoprotein binding2/43(155)
39GO:0005198structural molecule activity14/43(155)
38GO:0070062extracellular exosome3/36(156)
38GO:0005102receptor binding7/36(156)
38GO:0003735structural constituent of ribosome1/36(156)
38GO:0008061chitin binding1/36(156)
38GO:0008233peptidase activity2/36(156)
38GO:0004857enzyme inhibitor activity1/36(156)
907GO:0004386helicase activity1/6(22)
907GO:0000166nucleotide binding4/6(22)
33GO:0000166nucleotide binding26/44(168)
32GO:0002020protease binding1/58(170)
32GO:0016525negative regulation of angiogenesis2/58(170)
32GO:0005615extracellular space19/58(170)
32GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling1/58(170)
32GO:0004867serine-type endopeptidase inhibitor activity8/58(170)
31GO:0004252serine-type endopeptidase activity2/24(171)
31GO:0001964startle response2/24(171)
31GO:0016020membrane2/24(171)
31GO:0008344adult locomotory behavior2/24(171)
31GO:0003682chromatin binding1/24(171)
909GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activity3/7(22)
36GO:0005112Notch binding10/30(160)
36GO:0001047core promoter binding1/30(160)
36GO:0005509calcium ion binding5/30(160)
35GO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding2/37(166)
35GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding6/37(166)
35GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/37(166)
35GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding1/37(166)
35GO:0003677DNA binding3/37(166)
1459GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/3(17)
1245GO:0016491oxidoreductase activity2/2(17)
649GO:0005929cilium1/6(25)
649GO:0005622intracellular2/6(25)
648GO:0003677DNA binding5/6(25)
434GO:0016773phosphotransferase activity, alcohol group as acceptor1/8(32)
434GO:0043539protein serine/threonine kinase activator activity1/8(32)
431GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/9(32)
431GO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding1/9(32)
431GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/9(32)
431GO:0003677DNA binding1/9(32)
2615GO:0008017microtubule binding1/2(10)
339GO:0005347ATP transmembrane transporter activity3/8(35)
339GO:0006810transport1/8(35)
7623GO:0070062extracellular exosome2/2(7)
330GO:0005216ion channel activity2/8(36)
2618GO:0016757transferase activity, transferring glycosyl groups1/3(10)
9639GO:0004129cytochrome-c oxidase activity2/2(4)
1908GO:0000122negative regulation of transcription from RNA polymerase II promoter1/4(15)
9633GO:0003735structural constituent of ribosome2/2(4)
9635GO:0005783endoplasmic reticulum2/2(4)
3510GO:0017137Rab GTPase binding1/2(9)
2689GO:0016567protein ubiquitination1/2(10)
6GO:0005200structural constituent of cytoskeleton1/103(437)
6GO:1990126retrograde transport, endosome to plasma membrane2/103(437)
6GO:0007165signal transduction2/103(437)
6GO:0003676nucleic acid binding2/103(437)
6GO:0003950NAD+ ADP-ribosyltransferase activity2/103(437)
6GO:0035556intracellular signal transduction1/103(437)
6GO:0000122negative regulation of transcription from RNA polymerase II promoter1/103(437)
6GO:0000149SNARE binding1/103(437)
6GO:0019887protein kinase regulator activity1/103(437)
6GO:0004672protein kinase activity2/103(437)
6GO:0008134transcription factor binding2/103(437)
6GO:0090090negative regulation of canonical Wnt signaling pathway3/103(437)
6GO:0044212transcription regulatory region DNA binding1/103(437)
6GO:0005216ion channel activity2/103(437)
6GO:0017137Rab GTPase binding1/103(437)
6GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity2/103(437)
6GO:0045893positive regulation of transcription, DNA-templated2/103(437)
6GO:0007520myoblast fusion2/103(437)
6GO:0001085RNA polymerase II transcription factor binding2/103(437)
6GO:0010613positive regulation of cardiac muscle hypertrophy1/103(437)
6GO:0008093cytoskeletal adaptor activity1/103(437)
6GO:0016567protein ubiquitination3/103(437)
6GO:0005634nucleus2/103(437)
3892GO:0003677DNA binding1/2(9)
2680GO:0005044scavenger receptor activity1/1(10)
99GO:0005085guanyl-nucleotide exchange factor activity9/19(91)
90GO:0005198structural molecule activity18/37(97)
95GO:0004842ubiquitin-protein transferase activity1/21(95)
95GO:0008270zinc ion binding5/21(95)
1990GO:0004867serine-type endopeptidase inhibitor activity1/5(15)
1992GO:0003824catalytic activity1/3(15)
1216GO:0005737cytoplasm1/5(18)
1216GO:0005096GTPase activator activity2/5(18)
8835GO:0003676nucleic acid binding1/1(6)
2862GO:0003747translation release factor activity1/2(9)
2863GO:0005319lipid transporter activity2/2(9)
556GO:0044822poly(A) RNA binding1/4(27)
552GO:0001047core promoter binding1/6(28)
239GO:0003677DNA binding7/9(44)
3065GO:0004930G-protein coupled receptor activity2/2(9)
237GO:0016740transferase activity2/15(45)
237GO:0004307ethanolaminephosphotransferase activity1/15(45)
230GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/10(47)
230GO:0000979RNA polymerase II core promoter sequence-specific DNA binding2/10(47)
230GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/10(47)
230GO:0001047core promoter binding1/10(47)
231GO:0003824catalytic activity6/13(47)
2206GO:0000166nucleotide binding1/2(13)
2229GO:0005102receptor binding1/4(13)
1059GO:0016020membrane1/6(19)
147GO:0019901protein kinase binding1/12(61)
147GO:0016020membrane3/12(61)
147GO:0030220platelet formation1/12(61)
1173GO:0005509calcium ion binding3/5(18)
143GO:0003810protein-glutamine gamma-glutamyltransferase activity13/20(63)
140GO:0000150recombinase activity1/6(64)
140GO:0000166nucleotide binding2/6(64)
610GO:0008134transcription factor binding1/7(26)
610GO:0003677DNA binding3/7(26)
1274GO:0016020membrane2/4(17)
149GO:0048365Rac GTPase binding1/13(60)
149GO:0051015actin filament binding4/13(60)
615GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/6(26)
2122GO:0003676nucleic acid binding2/4(14)
947GO:0003677DNA binding4/5(22)
945GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/5(22)
945GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/5(22)
940GO:0004871signal transducer activity3/11(22)
1471GO:0001076transcription factor activity, RNA polymerase II transcription factor binding1/4(17)
1471GO:0003677DNA binding1/4(17)
689GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity6/8(25)
1474GO:0016020membrane1/4(17)
1190GO:0050890cognition2/4(18)
458GO:0005540hyaluronic acid binding5/8(31)
2710GO:0015179L-amino acid transmembrane transporter activity2/3(10)
2658GO:0044822poly(A) RNA binding1/2(10)
2595GO:0030433ER-associated ubiquitin-dependent protein catabolic process1/2(10)
2651GO:0003924GTPase activity2/3(10)
2719GO:0000166nucleotide binding1/3(10)
1308GO:0005102receptor binding2/4(17)
131GO:0005216ion channel activity7/13(69)
131GO:0005249voltage-gated potassium channel activity1/13(69)
130GO:0001849complement component C1q binding1/14(69)
130GO:0005178integrin binding1/14(69)
130GO:0005201extracellular matrix structural constituent2/14(69)
130GO:0005509calcium ion binding1/14(69)
498GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/5(29)
498GO:0003676nucleic acid binding2/5(29)
135GO:0000155phosphorelay sensor kinase activity3/15(65)
135GO:0005216ion channel activity1/15(65)
138GO:0014719skeletal muscle satellite cell activation2/12(64)
138GO:0005509calcium ion binding1/12(64)
490GO:0003950NAD+ ADP-ribosyltransferase activity2/7(30)
490GO:0004842ubiquitin-protein transferase activity1/7(30)
4223GO:0042803protein homodimerization activity1/2(8)
25GO:0004930G-protein coupled receptor activity13/66(229)
25GO:0001631cysteinyl leukotriene receptor activity2/66(229)
25GO:0001965G-protein alpha-subunit binding1/66(229)
25GO:0001530lipopolysaccharide binding2/66(229)
25GO:0004871signal transducer activity24/66(229)
26GO:0005200structural constituent of cytoskeleton54/166(216)
20GO:0004222metalloendopeptidase activity4/60(240)
20GO:0005524ATP binding11/60(240)
20GO:0000166nucleotide binding26/60(240)
625GO:0005506iron ion binding1/6(26)
625GO:0004051arachidonate 5-lipoxygenase activity1/6(26)
22GO:0005216ion channel activity31/52(233)
3795GO:0003231cardiac ventricle development2/2(9)
28GO:0048675axon extension2/39(187)
28GO:0002292T cell differentiation involved in immune response1/39(187)
28GO:0070062extracellular exosome1/39(187)
28GO:0016020membrane4/39(187)
28GO:0004888transmembrane signaling receptor activity2/39(187)
28GO:0004872receptor activity1/39(187)
28GO:0005886plasma membrane2/39(187)
28GO:0001843neural tube closure1/39(187)
28GO:0030215semaphorin receptor binding6/39(187)
29GO:0001756somitogenesis1/44(182)
29GO:0035064methylated histone binding2/44(182)
29GO:0030332cyclin binding1/44(182)
29GO:0003700transcription factor activity, sequence-specific DNA binding1/44(182)
29GO:0008017microtubule binding4/44(182)
29GO:0003713transcription coactivator activity2/44(182)
29GO:0003431growth plate cartilage chondrocyte development1/44(182)
29GO:0005198structural molecule activity2/44(182)
29GO:0006364rRNA processing1/44(182)
29GO:0019904protein domain specific binding3/44(182)
29GO:0008168methyltransferase activity1/44(182)
29GO:0001895retina homeostasis1/44(182)
29GO:0004842ubiquitin-protein transferase activity3/44(182)
29GO:0044822poly(A) RNA binding1/44(182)
29GO:0008270zinc ion binding2/44(182)
137GO:0000166nucleotide binding11/15(64)
1371GO:0016020membrane2/4(17)
2407GO:0016020membrane1/3(11)
2407GO:0003682chromatin binding1/3(11)
1373GO:0005154epidermal growth factor receptor binding1/4(17)
938GO:0003677DNA binding1/5(22)
2152GO:0003676nucleic acid binding1/3(14)
931GO:0015278calcium-release channel activity1/6(22)
931GO:0005096GTPase activator activity3/6(22)
935GO:0005654nucleoplasm1/4(22)
935GO:0001894tissue homeostasis1/4(22)
3831GO:0016567protein ubiquitination2/2(9)
10194GO:0019079viral genome replication1/1(2)
3564GO:0004418hydroxymethylbilane synthase activity2/2(9)
3247GO:0003723RNA binding1/2(9)
3847GO:0004045aminoacyl-tRNA hydrolase activity1/2(9)
825GO:0005096GTPase activator activity2/6(23)
825GO:0007165signal transduction1/6(23)
825GO:0002011morphogenesis of an epithelial sheet1/6(23)
373GO:0003950NAD+ ADP-ribosyltransferase activity3/8(33)
701GO:0003723RNA binding1/6(25)
701GO:0003676nucleic acid binding2/6(25)
701GO:0003677DNA binding1/6(25)
702GO:0003677DNA binding2/6(25)
393GO:0016020membrane1/8(33)
392GO:0003779actin binding2/9(33)
89GO:0000166nucleotide binding9/18(97)
396GO:0003779actin binding2/8(33)
396GO:0001725stress fiber1/8(33)
396GO:0001649osteoblast differentiation1/8(33)
396GO:0008092cytoskeletal protein binding2/8(33)
394GO:0000166nucleotide binding6/8(33)
81GO:0003779actin binding1/27(102)
81GO:0005856cytoskeleton4/27(102)
81GO:0010592positive regulation of lamellipodium assembly1/27(102)
81GO:0004721phosphoprotein phosphatase activity2/27(102)
81GO:0008092cytoskeletal protein binding2/27(102)
795GO:0019899enzyme binding4/5(24)
2301GO:0016020membrane2/5(13)
9388GO:0001567cholesterol 25-hydroxylase activity1/2(5)
7GO:0000166nucleotide binding21/107(435)
7GO:0000287magnesium ion binding5/107(435)
7GO:0004672protein kinase activity29/107(435)
5840GO:0001968fibronectin binding2/3(8)
1139GO:0000989transcription factor activity, transcription factor binding1/4(18)
3746GO:0003677DNA binding2/2(9)
2281GO:0004672protein kinase activity2/2(13)
1131GO:0000166nucleotide binding1/5(18)
1135GO:0003676nucleic acid binding3/4(18)
3741GO:0044822poly(A) RNA binding1/2(9)
244GO:0008233peptidase activity4/10(44)
244GO:0001968fibronectin binding1/10(44)
246GO:0008270zinc ion binding2/8(44)
243GO:0005509calcium ion binding1/9(44)
243GO:0019899enzyme binding1/9(44)
243GO:0002175protein localization to paranode region of axon1/9(44)
2886GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/2(9)
9440GO:0044822poly(A) RNA binding1/2(5)
1437GO:0004768stearoyl-CoA 9-desaturase activity4/4(17)
2063GO:0016020membrane1/3(15)
1432GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/3(17)
1433GO:0003712transcription cofactor activity1/4(17)
3396GO:0008283cell proliferation2/2(9)
2064GO:0070506high-density lipoprotein particle receptor activity1/5(15)
2064GO:0004857enzyme inhibitor activity2/5(15)
2574GO:0008168methyltransferase activity1/2(10)
2572GO:0010181FMN binding1/2(10)
1439GO:0008417fucosyltransferase activity4/4(17)
518GO:0004930G-protein coupled receptor activity1/9(29)
518GO:0004871signal transducer activity3/9(29)
1009GO:0005102receptor binding1/3(20)
2374GO:0016020membrane1/2(12)
513GO:0003677DNA binding1/6(29)
513GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding2/6(29)
513GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/6(29)
512GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity4/6(29)
517GO:0003779actin binding1/9(29)
1348GO:0004842ubiquitin-protein transferase activity1/4(17)
1348GO:0008270zinc ion binding2/4(17)
3592GO:0000166nucleotide binding1/2(9)
8502GO:0004842ubiquitin-protein transferase activity1/2(7)
10658GO:0004045aminoacyl-tRNA hydrolase activity1/1(2)
1221GO:0008017microtubule binding2/4(18)
1221GO:0016020membrane1/4(18)
1220GO:0003676nucleic acid binding2/8(18)
451GO:0007015actin filament organization1/6(31)
628GO:0016020membrane1/6(25)
628GO:0051965positive regulation of synapse assembly4/6(25)
1344GO:0005351sugar:proton symporter activity3/4(17)
455GO:0004871signal transducer activity2/5(31)
7917GO:0003677DNA binding1/1(7)
172GO:0001964startle response2/16(56)
172GO:0007409axonogenesis4/16(56)
172GO:0051965positive regulation of synapse assembly2/16(56)
172GO:0007399nervous system development2/16(56)
2051GO:0003723RNA binding2/5(15)
973GO:0004622lysophospholipase activity1/6(21)
2054GO:0003824catalytic activity1/2(15)
2059GO:0003676nucleic acid binding2/4(15)
2059GO:0004672protein kinase activity1/4(15)
2889GO:0003830beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity1/2(9)
183GO:0044822poly(A) RNA binding2/15(55)
183GO:0007601visual perception2/15(55)
183GO:0005212structural constituent of eye lens4/15(55)
183GO:0042803protein homodimerization activity1/15(55)
181GO:0005178integrin binding2/14(55)
181GO:0005520insulin-like growth factor binding5/14(55)
187GO:0005201extracellular matrix structural constituent2/12(52)
650GO:0005520insulin-like growth factor binding5/6(25)
3879GO:0004864protein phosphatase inhibitor activity2/2(9)
2627GO:0016020membrane3/3(10)
10407GO:0000166nucleotide binding1/1(2)
3872GO:0000287magnesium ion binding1/2(9)
3873GO:0004871signal transducer activity2/2(9)
1125GO:0007155cell adhesion2/4(18)
8574GO:0016020membrane2/2(6)
3595GO:0031397negative regulation of protein ubiquitination2/2(9)
8479GO:0002039p53 binding1/2(7)
8479GO:0008270zinc ion binding1/2(7)
1911GO:0042325regulation of phosphorylation1/4(15)
1911GO:0004865protein serine/threonine phosphatase inhibitor activity1/4(15)
1910GO:0016020membrane2/2(15)
10011GO:0005739mitochondrion2/2(3)
1227GO:0008270zinc ion binding3/4(18)
10GO:0005509calcium ion binding34/114(380)
13GO:0004984olfactory receptor activity3/94(336)
13GO:0004871signal transducer activity31/94(336)
13GO:0003707steroid hormone receptor activity1/94(336)
12GO:0004930G-protein coupled receptor activity6/93(341)
12GO:0004871signal transducer activity51/93(341)
12GO:0001626nociceptin receptor activity2/93(341)
12GO:0001596angiotensin type I receptor activity2/93(341)
12GO:0003779actin binding2/93(341)
12GO:0001965G-protein alpha-subunit binding1/93(341)
12GO:0002020protease binding2/93(341)
15GO:0004725protein tyrosine phosphatase activity7/74(303)
15GO:0008134transcription factor binding1/74(303)
15GO:0004721phosphoprotein phosphatase activity27/74(303)
15GO:0001784phosphotyrosine binding4/74(303)
15GO:0003712transcription cofactor activity1/74(303)
8188GO:0000502proteasome complex2/2(7)
17GO:0004672protein kinase activity7/57(257)
17GO:0002039p53 binding1/57(257)
17GO:0000166nucleotide binding22/57(257)
16GO:0003676nucleic acid binding14/69(264)
16GO:0000166nucleotide binding25/69(264)
19GO:0004890GABA-A receptor activity24/58(244)
19GO:0005230extracellular ligand-gated ion channel activity10/58(244)
19GO:0006811ion transport1/58(244)
18GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs2/66(256)
18GO:0004930G-protein coupled receptor activity1/66(256)
18GO:0001594trace-amine receptor activity1/66(256)
18GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/Go4/66(256)
18GO:0001587Gq/11-coupled serotonin receptor activity2/66(256)
18GO:0001965G-protein alpha-subunit binding2/66(256)
18GO:0004871signal transducer activity28/66(256)
3441GO:0005092GDP-dissociation inhibitor activity2/2(9)
8182GO:0006506GPI anchor biosynthetic process2/2(7)
9623GO:0005654nucleoplasm1/1(4)
2022GO:0008536Ran GTPase binding2/2(15)
2023GO:0016301kinase activity1/3(15)
2697GO:0016020membrane2/2(10)
883GO:0030534adult behavior1/4(23)
886GO:0004871signal transducer activity4/6(22)
2623GO:0003723RNA binding1/3(10)
9752GO:0001664G-protein coupled receptor binding2/2(3)
8848GO:0006508proteolysis1/2(6)
325GO:0008277regulation of G-protein coupled receptor protein signaling pathway3/9(36)
204GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3/11(49)
204GO:0046983protein dimerization activity4/11(49)
207GO:0004197cysteine-type endopeptidase activity1/14(49)
207GO:0036459thiol-dependent ubiquitinyl hydrolase activity3/14(49)
207GO:0004843thiol-dependent ubiquitin-specific protease activity3/14(49)
209GO:0009986cell surface3/10(49)
209GO:0016020membrane2/10(49)
2879GO:0000070mitotic sister chromatid segregation2/2(9)
76GO:0001948glycoprotein binding1/22(105)
76GO:0005576extracellular region1/22(105)
76GO:0001657ureteric bud development2/22(105)
75GO:0005179hormone activity2/25(107)
75GO:0005125cytokine activity2/25(107)
75GO:0004745retinol dehydrogenase activity1/25(107)
75GO:0008083growth factor activity11/25(107)
74GO:0004872receptor activity12/27(108)
74GO:0004970ionotropic glutamate receptor activity3/27(108)
3055GO:0005212structural constituent of eye lens1/2(9)
79GO:0004175endopeptidase activity1/29(103)
79GO:0004222metalloendopeptidase activity19/29(103)
78GO:0005216ion channel activity2/14(103)
78GO:0005245voltage-gated calcium channel activity1/14(103)
1042GO:0006886intracellular protein transport2/7(20)
1042GO:0005198structural molecule activity3/7(20)
1048GO:0019208phosphatase regulator activity2/5(20)
1048GO:0004857enzyme inhibitor activity2/5(20)
1760GO:0008022protein C-terminus binding2/3(16)
1268GO:0005104fibroblast growth factor receptor binding4/4(17)
1148GO:0044822poly(A) RNA binding1/3(18)
1260GO:0005319lipid transporter activity2/7(17)
1267GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/4(17)
9475GO:0008121ubiquinol-cytochrome-c reductase activity3/3(4)
2094GO:0005524ATP binding2/5(14)
2525GO:0007126meiotic nuclear division1/3(11)
1540GO:0005319lipid transporter activity2/5(16)
2486GO:0003677DNA binding1/2(11)
7615GO:0003824catalytic activity1/1(8)
699GO:0000166nucleotide binding2/4(25)
2248GO:0016020membrane1/3(13)
544GO:0004871signal transducer activity4/8(28)
1465GO:0000049tRNA binding2/7(17)
1465GO:0016757transferase activity, transferring glycosyl groups1/7(17)
8GO:0003774motor activity3/108(417)
8GO:0007165signal transduction1/108(417)
8GO:0000146microfilament motor activity8/108(417)
8GO:0000166nucleotide binding38/108(417)
1467GO:0001784phosphotyrosine binding2/4(17)
2240GO:0016020membrane1/4(13)
2718GO:0003777microtubule motor activity1/2(10)
68GO:0004089carbonate dehydratase activity13/26(110)
68GO:0004064arylesterase activity2/26(110)
9378GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/1(5)
1313GO:0001666response to hypoxia2/4(17)
2707GO:0003779actin binding1/2(10)
2706GO:0043522leucine zipper domain binding1/3(10)
120GO:0004252serine-type endopeptidase activity2/14(75)
120GO:0004175endopeptidase activity4/14(75)
120GO:0002020protease binding1/14(75)
122GO:0005737cytoplasm2/19(74)
122GO:0005634nucleus1/19(74)
122GO:0001965G-protein alpha-subunit binding3/19(74)
122GO:0005096GTPase activator activity3/19(74)
123GO:0003677DNA binding15/21(73)
124GO:0000166nucleotide binding12/14(73)
764GO:0016787hydrolase activity1/4(24)
126GO:0008146sulfotransferase activity11/19(71)
127GO:0003779actin binding1/16(70)
127GO:0005216ion channel activity5/16(70)
1825GO:0004867serine-type endopeptidase inhibitor activity2/4(16)
2410GO:0003729mRNA binding1/3(11)
2799GO:0019901protein kinase binding1/2(9)
2415GO:0016020membrane4/5(11)
1405GO:0016020membrane3/4(17)
2141GO:0006810transport2/4(14)
413GO:0003779actin binding2/7(32)
2060GO:0003755peptidyl-prolyl cis-trans isomerase activity4/4(15)
1385GO:0031593polyubiquitin binding2/4(17)
1387GO:0005524ATP binding3/4(17)
418GO:0008565protein transporter activity3/6(32)
2795GO:0007596blood coagulation1/2(9)
3820GO:0007186G-protein coupled receptor signaling pathway1/2(9)
3889GO:0045600positive regulation of fat cell differentiation1/3(9)
9091GO:0005509calcium ion binding1/2(6)
9093GO:0003824catalytic activity2/2(6)
8444GO:0010629negative regulation of gene expression1/1(7)
9653GO:0003743translation initiation factor activity2/2(4)
9656GO:0003735structural constituent of ribosome2/2(4)
9657GO:0016020membrane2/2(4)
8442GO:0008121ubiquinol-cytochrome-c reductase activity2/3(7)
1927GO:0004129cytochrome-c oxidase activity1/4(15)
1929GO:0003677DNA binding1/6(15)
2667GO:0003676nucleic acid binding1/2(10)
3GO:0000287magnesium ion binding1/139(535)
3GO:0000166nucleotide binding72/139(535)
3GO:0003779actin binding2/139(535)
3GO:0004713protein tyrosine kinase activity1/139(535)
3GO:0004672protein kinase activity11/139(535)
3GO:0005524ATP binding1/139(535)
362GO:0000166nucleotide binding7/8(34)
2668GO:0003735structural constituent of ribosome3/3(10)
2935GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity1/2(9)
9253GO:0051090regulation of sequence-specific DNA binding transcription factor activity1/1(5)
383GO:0003677DNA binding9/11(33)
406GO:0002244hematopoietic progenitor cell differentiation2/8(33)
406GO:0006367transcription initiation from RNA polymerase II promoter1/8(33)
406GO:0003677DNA binding1/8(33)
389GO:0005158insulin receptor binding1/9(33)
389GO:0006357regulation of transcription from RNA polymerase II promoter1/9(33)
21GO:0001221transcription cofactor binding1/62(240)
21GO:0001046core promoter sequence-specific DNA binding2/62(240)
21GO:0000166nucleotide binding1/62(240)
21GO:0001105RNA polymerase II transcription coactivator activity2/62(240)
21GO:0003676nucleic acid binding5/62(240)
21GO:0003677DNA binding6/62(240)
21GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3/62(240)
21GO:0003682chromatin binding3/62(240)
21GO:0005524ATP binding12/62(240)
1728GO:0006974cellular response to DNA damage stimulus1/3(16)
9398GO:0003735structural constituent of ribosome1/2(5)
5978GO:0000166nucleotide binding2/3(8)
151GO:0004707MAP kinase activity1/18(60)
151GO:0000287magnesium ion binding1/18(60)
151GO:0004672protein kinase activity1/18(60)
151GO:0000166nucleotide binding7/18(60)
578GO:0005102receptor binding2/7(27)
604GO:0042802identical protein binding1/7(26)
604GO:0001656metanephros development1/7(26)
604GO:0001846opsonin binding2/7(26)
3750GO:0030507spectrin binding1/2(9)
571GO:0001540beta-amyloid binding5/7(27)
570GO:0008270zinc ion binding3/6(27)
2294GO:0005159insulin-like growth factor receptor binding1/4(13)
2294GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway2/4(13)
61GO:0008284positive regulation of cell proliferation1/24(119)
61GO:0005102receptor binding4/24(119)
61GO:0000904cell morphogenesis involved in differentiation1/24(119)
61GO:0001764neuron migration1/24(119)
61GO:0005201extracellular matrix structural constituent1/24(119)
63GO:0001641group II metabotropic glutamate receptor activity4/24(116)
63GO:0004871signal transducer activity8/24(116)
3001GO:0005737cytoplasm2/2(9)
2195GO:0004930G-protein coupled receptor activity3/4(13)
66GO:0001085RNA polymerase II transcription factor binding1/22(115)
66GO:0001105RNA polymerase II transcription coactivator activity1/22(115)
66GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/22(115)
66GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding5/22(115)
66GO:0003677DNA binding5/22(115)
67GO:0005216ion channel activity7/22(112)
252GO:0019992diacylglycerol binding4/7(42)
252GO:0030742GTP-dependent protein binding1/7(42)
69GO:0003779actin binding5/25(109)
69GO:0003725double-stranded RNA binding1/25(109)
69GO:0005509calcium ion binding3/25(109)
251GO:0009922fatty acid elongase activity3/11(43)
251GO:0001104RNA polymerase II transcription cofactor activity2/11(43)
251GO:0016740transferase activity2/11(43)
256GO:0051082unfolded protein binding5/11(42)
2202GO:0005096GTPase activator activity2/3(13)
2203GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity3/4(13)
1427GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/3(17)
7695GO:0001530lipopolysaccharide binding1/2(7)
405GO:0003779actin binding1/9(33)
405GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen1/9(33)
509GO:0004497monooxygenase activity4/8(29)
509GO:0005506iron ion binding1/8(29)
503GO:0003677DNA binding2/6(29)
630GO:0003677DNA binding5/7(25)
1211GO:0008381mechanically-gated ion channel activity1/4(18)
634GO:0032947protein complex scaffold2/6(25)
401GO:0046872metal ion binding2/8(33)
401GO:0003677DNA binding1/8(33)
638GO:0035091phosphatidylinositol binding3/6(25)
638GO:00055451-phosphatidylinositol binding1/6(25)
1218GO:0003779actin binding2/5(18)
466GO:0001970positive regulation of activation of membrane attack complex2/8(31)
466GO:0006955immune response5/8(31)
2424GO:0045576mast cell activation1/2(11)
9505GO:0019899enzyme binding1/2(4)
5655GO:0003824catalytic activity1/1(8)
161GO:0003824catalytic activity1/10(57)
161GO:0007165signal transduction1/10(57)
161GO:0042803protein homodimerization activity2/10(57)
163GO:0004177aminopeptidase activity3/12(57)
163GO:0008237metallopeptidase activity3/12(57)
163GO:0006508proteolysis1/12(57)
967GO:0003993acid phosphatase activity3/6(21)
960GO:0003824catalytic activity1/5(21)
961GO:0006479protein methylation1/5(21)
961GO:0019899enzyme binding1/5(21)
963GO:0003690double-stranded DNA binding2/5(21)
963GO:0003677DNA binding1/5(21)
969GO:0008289lipid binding2/3(21)
2893GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding1/2(9)
2892GO:0005737cytoplasm1/2(9)
110GO:0005215transporter activity15/23(83)
1456GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/5(17)
1456GO:0001159core promoter proximal region DNA binding1/5(17)
2408GO:0003677DNA binding2/3(11)
9438GO:0004842ubiquitin-protein transferase activity1/2(5)
9434GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c2/2(5)
1510GO:0000900translation repressor activity, nucleic acid binding1/3(16)
2104GO:0003725double-stranded RNA binding4/5(14)
9342GO:0001601peptide YY receptor activity2/3(5)
30GO:0017147Wnt-protein binding1/37(182)
30GO:0001540beta-amyloid binding1/37(182)
30GO:0005041low-density lipoprotein receptor activity2/37(182)
30GO:0005509calcium ion binding6/37(182)
30GO:0001948glycoprotein binding1/37(182)
2738GO:0000166nucleotide binding1/3(10)
10368GO:0009116nucleoside metabolic process1/1(2)
584GO:0004415hyalurononglucosaminidase activity2/7(27)
584GO:0098641cadherin binding involved in cell-cell adhesion2/7(27)
7805GO:0016787hydrolase activity1/2(7)
34GO:0001948glycoprotein binding1/45(166)
34GO:0005178integrin binding1/45(166)
34GO:0005102receptor binding2/45(166)
34GO:0005509calcium ion binding28/45(166)
877GO:0005085guanyl-nucleotide exchange factor activity4/5(23)
875GO:0002244hematopoietic progenitor cell differentiation1/4(23)
1818GO:0016020membrane3/5(16)
870GO:0000166nucleotide binding3/6(23)
871GO:0017112Rab guanyl-nucleotide exchange factor activity2/5(23)
3185GO:0000166nucleotide binding1/2(9)
2742GO:0046872metal ion binding1/2(10)
2742GO:0008270zinc ion binding1/2(10)
2033GO:0006810transport2/3(15)
3182GO:0004672protein kinase activity2/2(9)
9GO:0007626locomotory behavior1/100(386)
9GO:0000070mitotic sister chromatid segregation1/100(386)
9GO:0000902cell morphogenesis2/100(386)
9GO:0005783endoplasmic reticulum1/100(386)
9GO:0006355regulation of transcription, DNA-templated2/100(386)
9GO:0002467germinal center formation2/100(386)
9GO:0051015actin filament binding1/100(386)
9GO:0003779actin binding6/100(386)
9GO:0016567protein ubiquitination8/100(386)
9GO:2001243negative regulation of intrinsic apoptotic signaling pathway1/100(386)
9GO:0007010cytoskeleton organization1/100(386)
9GO:0031397negative regulation of protein ubiquitination2/100(386)
9GO:2000312regulation of kainate selective glutamate receptor activity2/100(386)
9GO:0004842ubiquitin-protein transferase activity4/100(386)
9GO:0006446regulation of translational initiation3/100(386)
9GO:0042802identical protein binding3/100(386)
9GO:0005615extracellular space2/100(386)
2039GO:0000993RNA polymerase II core binding1/5(15)
895GO:0003677DNA binding1/9(22)
896GO:0038131neuregulin receptor activity1/4(22)
6343GO:0044822poly(A) RNA binding2/2(8)
3540GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/2(9)
1970GO:0005198structural molecule activity3/3(15)
3287GO:0000166nucleotide binding1/2(9)
46GO:0004435phosphatidylinositol phospholipase C activity14/34(146)
46GO:0001786phosphatidylserine binding2/34(146)
352GO:0000932cytoplasmic mRNA processing body1/9(34)
352GO:0021987cerebral cortex development1/9(34)
351GO:0070062extracellular exosome2/5(34)
807GO:0007017microtubule-based process6/6(24)
806GO:0004364glutathione transferase activity8/8(24)
805GO:0006810transport1/6(24)
216GO:0004137deoxycytidine kinase activity1/14(48)
216GO:0005524ATP binding2/14(48)
216GO:0005509calcium ion binding3/14(48)
2963GO:0070062extracellular exosome1/2(9)
762GO:0044822poly(A) RNA binding3/4(24)
2843GO:0035556intracellular signal transduction1/2(9)
218GO:0016020membrane3/13(48)
218GO:0004745retinol dehydrogenase activity2/13(48)
2971GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity1/1(9)
1076GO:0002039p53 binding2/3(19)
1077GO:0017025TBP-class protein binding1/6(19)
1077GO:0010265SCF complex assembly1/6(19)
1074GO:0003824catalytic activity2/5(19)
1074GO:0003730mRNA 3'-UTR binding2/5(19)
1075GO:0003824catalytic activity2/3(19)
1073GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity3/4(19)
1070GO:0000166nucleotide binding4/8(19)
288GO:0007155cell adhesion2/7(40)
288GO:0019903protein phosphatase binding1/7(40)
288GO:0005518collagen binding2/7(40)
4GO:0001948glycoprotein binding1/119(497)
4GO:0004252serine-type endopeptidase activity50/119(497)
4GO:0004175endopeptidase activity2/119(497)
1674GO:0005765lysosomal membrane1/5(16)
1674GO:0016020membrane1/5(16)
285GO:0005245voltage-gated calcium channel activity5/7(40)
1094GO:0005509calcium ion binding2/4(19)
1097GO:0003677DNA binding1/5(19)
1097GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/5(19)
1097GO:0000182rDNA binding2/5(19)
1159GO:0004175endopeptidase activity1/5(18)
1159GO:0004190aspartic-type endopeptidase activity3/5(18)
7809GO:0003677DNA binding1/2(7)
3136GO:0044822poly(A) RNA binding2/2(9)
267GO:0001664G-protein coupled receptor binding1/10(41)
267GO:0005524ATP binding1/10(41)
267GO:0051082unfolded protein binding2/10(41)
265GO:0000166nucleotide binding3/11(42)
264GO:0004871signal transducer activity10/12(42)
3641GO:0035064methylated histone binding2/2(9)
58GO:0000166nucleotide binding21/30(122)
2553GO:0006810transport2/2(10)
2555GO:0005337nucleoside transmembrane transporter activity2/2(10)
1557GO:0004720protein-lysine 6-oxidase activity1/3(16)
3034GO:0003676nucleic acid binding2/2(9)
1558GO:0005215transporter activity2/3(16)
7605GO:0000166nucleotide binding1/2(8)
56GO:0004888transmembrane signaling receptor activity2/34(130)
56GO:0004871signal transducer activity20/34(130)
51GO:0048306calcium-dependent protein binding2/31(135)
51GO:0000149SNARE binding3/31(135)
51GO:0006887exocytosis1/31(135)
51GO:0005544calcium-dependent phospholipid binding2/31(135)
51GO:0017158regulation of calcium ion-dependent exocytosis1/31(135)
51GO:0005509calcium ion binding4/31(135)
51GO:0001786phosphatidylserine binding1/31(135)
51GO:0017156calcium ion regulated exocytosis1/31(135)
53GO:0000975regulatory region DNA binding1/39(133)
53GO:0001972retinoic acid binding1/39(133)
53GO:0000976transcription regulatory region sequence-specific DNA binding1/39(133)
53GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding6/39(133)
53GO:0001046core promoter sequence-specific DNA binding2/39(133)
53GO:0003677DNA binding9/39(133)
53GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding4/39(133)
53GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3/39(133)
52GO:0005242inward rectifier potassium channel activity21/35(134)
2396GO:0070062extracellular exosome1/4(12)
55GO:0001948glycoprotein binding1/29(130)
55GO:0001764neuron migration1/29(130)
55GO:0002020protease binding2/29(130)
55GO:0007155cell adhesion4/29(130)
55GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules1/29(130)
55GO:0086080protein binding involved in heterotypic cell-cell adhesion1/29(130)
55GO:0005112Notch binding2/29(130)
55GO:0030506ankyrin binding2/29(130)
54GO:0000166nucleotide binding20/33(131)
64GO:0000166nucleotide binding19/28(116)
1448GO:0005524ATP binding1/2(17)
1414GO:0032403protein complex binding1/5(17)
2493GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/2(11)
65GO:0016020membrane1/24(116)
65GO:0004222metalloendopeptidase activity5/24(116)
65GO:0004872receptor activity2/24(116)
65GO:0005518collagen binding1/24(116)
65GO:0005509calcium ion binding2/24(116)
2474GO:0005634nucleus1/3(11)
1324GO:0003746translation elongation factor activity3/4(17)
2772GO:0003676nucleic acid binding1/3(10)
981GO:0008013beta-catenin binding2/4(21)
984GO:0001530lipopolysaccharide binding2/6(21)
2802GO:0005112Notch binding2/2(9)
111GO:0005201extracellular matrix structural constituent1/21(82)
111GO:0005615extracellular space3/21(82)
111GO:0044822poly(A) RNA binding1/21(82)
111GO:0031012extracellular matrix2/21(82)
111GO:0002020protease binding1/21(82)
111GO:0035987endodermal cell differentiation2/21(82)
7601GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds1/2(8)
119GO:0016787hydrolase activity4/22(75)
119GO:0042043neurexin family protein binding4/22(75)
119GO:0003990acetylcholinesterase activity2/22(75)
119GO:0004771sterol esterase activity1/22(75)
118GO:0016301kinase activity8/20(77)
118GO:0046854phosphatidylinositol phosphorylation1/20(77)
118GO:0000166nucleotide binding2/20(77)
1256GO:0003824catalytic activity1/4(17)
2173GO:0016787hydrolase activity2/4(14)
2173GO:0016208AMP binding2/4(14)
2078GO:0004930G-protein coupled receptor activity2/3(14)
1399GO:0000149SNARE binding2/4(17)
1399GO:0004672protein kinase activity2/4(17)
9546GO:0016787hydrolase activity1/2(4)
9546GO:0008768UDP-sugar diphosphatase activity1/2(4)
1396GO:0016787hydrolase activity1/5(17)
1396GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity1/5(17)
9544GO:0003735structural constituent of ribosome1/1(4)
425GO:0008375acetylglucosaminyltransferase activity3/5(32)
425GO:0015020glucuronosyltransferase activity1/5(32)
910GO:0000166nucleotide binding4/8(22)
309GO:0016020membrane1/7(38)
309GO:0005086ARF guanyl-nucleotide exchange factor activity2/7(38)
300GO:0008092cytoskeletal protein binding1/7(38)
301GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity4/8(38)
3819GO:0003723RNA binding1/2(9)
2608GO:0003824catalytic activity2/2(10)
1932GO:0032332positive regulation of chondrocyte differentiation1/4(15)
1932GO:0003677DNA binding2/4(15)
1935GO:0003700transcription factor activity, sequence-specific DNA binding1/6(15)
3508GO:0003824catalytic activity1/2(9)
842GO:0005543phospholipid binding2/6(23)
842GO:0048156tau protein binding1/6(23)
841GO:0007155cell adhesion1/3(23)
3502GO:0006891intra-Golgi vesicle-mediated transport1/2(9)
3503GO:0008270zinc ion binding1/2(9)
3504GO:0006281DNA repair1/2(9)
3507GO:0008080N-acetyltransferase activity1/2(9)
2678GO:0070062extracellular exosome1/2(10)
2926GO:0003958NADPH-hemoprotein reductase activity2/2(9)
9035GO:0005179hormone activity1/2(6)
3166GO:0044822poly(A) RNA binding2/2(9)
1985GO:0046983protein dimerization activity2/3(15)
1921GO:0000166nucleotide binding4/4(15)
753GO:0000166nucleotide binding1/5(24)
752GO:0016757transferase activity, transferring glycosyl groups2/6(24)
3604GO:0003676nucleic acid binding2/2(9)
560GO:0003676nucleic acid binding1/5(27)
736GO:0005070SH3/SH2 adaptor activity3/5(24)
566GO:0008017microtubule binding2/6(27)
3073GO:0002244hematopoietic progenitor cell differentiation1/2(9)
2186GO:0090002establishment of protein localization to plasma membrane2/3(14)
229GO:0005216ion channel activity4/13(47)
225GO:0005215transporter activity8/12(48)
225GO:0001972retinoic acid binding2/12(48)
224GO:0004872receptor activity5/11(48)
222GO:0005509calcium ion binding3/8(48)
114GO:0004620phospholipase activity8/22(79)
1186GO:0070273phosphatidylinositol-4-phosphate binding2/5(18)
1186GO:0019899enzyme binding2/5(18)
2736GO:0003779actin binding3/3(10)
723GO:0003824catalytic activity3/4(24)
2351GO:0048407platelet-derived growth factor binding1/2(12)
6146GO:0031625ubiquitin protein ligase binding1/1(8)
605GO:0044822poly(A) RNA binding2/6(26)
605GO:0003723RNA binding1/6(26)
1165GO:0004871signal transducer activity2/4(18)
155GO:0003677DNA binding4/14(59)
1161GO:0003676nucleic acid binding2/4(18)
157GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding4/13(58)
157GO:0000979RNA polymerase II core promoter sequence-specific DNA binding2/13(58)
157GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/13(58)
157GO:0003677DNA binding2/13(58)
1163GO:0008146sulfotransferase activity2/5(18)
8073GO:0006810transport1/2(7)
3739GO:0008289lipid binding2/2(9)
1895GO:0004639phosphoribosylaminoimidazolesuccinocarboxamide synthase activity1/3(16)
7832GO:0016020membrane1/2(7)
468GO:0005319lipid transporter activity4/10(31)
2134GO:0003682chromatin binding2/4(14)
951GO:0004842ubiquitin-protein transferase activity2/4(21)
951GO:0008270zinc ion binding1/4(21)
44GO:0004497monooxygenase activity26/47(148)
44GO:0005506iron ion binding2/47(148)
45GO:0016740transferase activity11/36(147)
45GO:0004653polypeptide N-acetylgalactosaminyltransferase activity10/36(147)
42GO:0005283sodium:amino acid symporter activity1/44(151)
42GO:0005328neurotransmitter:sodium symporter activity31/44(151)
42GO:0005298proline:sodium symporter activity2/44(151)
956GO:0050770regulation of axonogenesis2/5(21)
9428GO:0005654nucleoplasm1/1(5)
1113GO:0006952defense response1/2(19)
1444GO:0016020membrane1/4(17)
5GO:0000287magnesium ion binding2/130(478)
5GO:0000166nucleotide binding70/130(478)
5GO:0004674protein serine/threonine kinase activity1/130(478)
5GO:0004672protein kinase activity10/130(478)
5GO:0046872metal ion binding1/130(478)
5GO:0002039p53 binding2/130(478)
8675GO:0008168methyltransferase activity1/2(6)
1440GO:0044822poly(A) RNA binding2/4(17)
1292GO:0004842ubiquitin-protein transferase activity1/4(17)
9420GO:0004359glutaminase activity1/2(5)
2500GO:0003677DNA binding1/1(11)
2648GO:0005737cytoplasm1/3(10)
1357GO:0005154epidermal growth factor receptor binding2/4(17)
1354GO:0008092cytoskeletal protein binding2/4(17)
678GO:0008201heparin binding2/6(25)
678GO:0005524ATP binding2/6(25)
3197GO:0016491oxidoreductase activity1/2(9)
473GO:0035641locomotory exploration behavior1/8(30)