Node summary

Genes16260
Ancestral nodeBOP5

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CAFE summary

Expansions314 (40 rapid)
Contractions455 (31 rapid)
Extinctions135

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Family IDGene CountChangeRapid (*)?Exctinction (--)?
2706+1
2744-1
9811-2
9113+1
907-3*
9513+1
9412-6*
9715+3*
11722-1
8752-1
6204+1
8702-1
6253-1
20393+1
3934-1
3985+1
23011-1
37472+1
1797-1
1768+1
1757-1
1702-2*
6992-2*
2588+2*
2525-1
2534-1
2555-1
25191-1
25111-1
25121-1
25131-1
11563+1
21821-1
21861-1
21851-1
21891-1
1508+1
1537-1
1578+1
1598+3*
1587-1
97772+1*
8192-1
8142-1
20971-1
30202+1
2399+3*
2355-1
2376+1
2338+3*
25381-1
25321-1
25332+1
25301-1
25361-1
25341-1
9382-1
9331-2
9324+1
9342-1
93980-1--
93880-1--
21451-1
7982-1
24152+1*
11333+1
11313+1
11362-1
11353+1
11343+1
21493+1
85030-1--
282-3
27092+1
4753-1
97140-1--
8384+1
17211-1
94540-1--
91040-1--
94510-1--
24162+1
2147+1
2129+2
2116-1
2198+1
25502+1
25520-2*--
25532+1
9182-1
9152-1
6324+1
6353-1
11111-1
14493+1
1956-5*
27632+1
11833+1
97390-1--
34522+1
656-3
13082-1
4933-1
39392+1
4463-1
25742+1*
25702+1
6534+1
3184-2*
3124-1
3176+1
3154-1
3145+1
4435+1
4415+1
22931-1
22922+1
22911-1
22941-1
8745+1
8732-1
20381-1
10951-2*
10992-1
19151-1
13223+1
9552-1
96740-1--
96760-1--
96770-1--
96710-1--
96780-1--
16622-1
5933-1
28242+1
28272+1
28212+1
33802+1
3395+1
3304-1
94480-1--
94470-1--
94460-1--
94450-1--
94440-1--
94410-1--
94400-1--
20151-1
20142+1*
20163+1
94430-1--
94420-1--
13493+1
4513-1
4546+2
8332-1
39732+1
36232+1
94330-1--
29532+1
24651-1
24602+1
10202-1
96560-1--
5774+1
28053+2*
14273+1
33622+1
42792+1
12003+1
3554-1
3536+1
3514-1
21930-1--
22591-1
20701-1
20753+1
4796+2
2964-1
2946+1
24401-1
24411-1
24471-1
24482+1
96320-1--
96350-1--
28662+1*
28672+1
5544+1
5533-1
5523-1
3775+1
3765+1
61461-1
22761-1
20551-1
20541-1
13871-1
4184-1
24203+1
28402+1
33232+1
5353-1
30352+1
5383-1
38172+1
94280-1--
10182-1
10144+1
10154+2
10102-1
10124+1
4324-1
4313-1
10522-1
10562-1
32402+1
19901-1
6122-1
6134+1
5135+1
5155+1
5165+1
12261-2*
6214+1
6282-1
12293+1
38751-1
84790-1--
84780-1--
84740-1--
84770-1--
84760-1--
84710-1--
84700-1--
84730-1--
22352+1
22361-1
34941-1
20941-1
20981-1
364-1
10342-1
23962+1
23951-1
23901-1
21771-1
19303+1
19351-1
103770-1--
41422+1
26152+1
26131-1
26122+1
11873+1
29432+1
10512-1
10532-1
31162+1
760+2
23744+3*
23721-1
49482+1
19183+1
8862-1
8892-1
8882-2*
76140-1--
76100-1--
76120-1--
56892+1
25861-1
25822+1
25802+1
2804-2*
100030-1--
95960-1--
10793+1
29742+1
10433+1
10402-1
23592+1
23551-1
37332+1
27870-2*--
27832+1
27822+1
6604+1
68452+1
76342+1
10253+1
76130-1--
38920-2*--
38900-1--
26592+1
26582+1
26502+1
26572+1
90680-1--
7084+1
7054+1
24862+1
24872+1
31562+1
31541-1
24801-1
5683-1
23371-1
23381-1
37152+1
37102+1
12010-1
1216-4*
12311+2
12412+2
1259+2
1268-1
12811+1
1298-1
68272+1
15192-1
15103+1
2606+1
2655-1
2644-1
2697+1
9882-1
9841-2
90880-1--
90870-1--
90860-1--
90850-1--
90840-1--
90830-1--
90820-1--
90800-1--
7233-1
4715+1
4765+1
27850-2--
4774-1
23184+3*
23170-1--
23132+1
23111-1
1009-2
10116+3*
10417+5*
10511+1
100010-1--
97450-1--
17573+1
12863+1
12803+1
12893+1
12882-1
6843-1
6873-1
85000-1--
85020-1--
85050-1--
85040-1--
12433+1
84930-1--
84910-1--
84900-1--
84970-1--
84940-1--
84990-1--
84980-1--
2444-2
2476+1
2435-1
36901-1
13623+1
11483+1
38015+11*
3814-1
3845+1
3854-1
3874-1
10743+1
37542+1
21911-2*
21951-1
1695-1
1658+2*
1616-2*
1626-2*
1636-1
27352+1
27302+1
8093-1
8003-1
8062-1
8054+2*
30362+1
30332+1
2257+1
2247+1
2217+2
25061-1
25052+1
25031-1
25011-1
25001-1
12561-1
11293+1
28681-1
27052+1
1468+1
1442-4*
14010-1
1488+1
27162+1
33462+1
8292-1
8254+1
8242-1
8273-1
8262-1
8212-1
1142-1
1041-3
1350+6*
1241-1
1438-1
1630-3
1931-1
1831-1
2006-2*
2046-1
2077+1
2098+1
8354+1
25252+1
25242+1
25231-1
7864+1
23572+1*
4047+3
93970-1--
11032-1
465-1
8422-1
8412-1
24030-2*--
4883-1
4865+1
4843-1
4833-1
36712+1
25431-1
25421-1
25411-1
25401-1
25471-1
25462+1
9092-1
14751-1
14782-1
2431+1
2529+1
262-1
2126-4
2326-2
2824-1
10683+1
10672-1
10661-2*
22813+2*
22831-1
1866-1
1877+1
1845-3*
1858+1
34402+1
8672-1
20271-2*
30512+1
854+3
40522+1
25692+1
25603+2*
25622+1
25672+1
9644+1
9612-1
15324+2
12483+1
6434+1
16761-1
6424+1
6473-1
3052-2*
91030-1--
91000-1--
91010-1--
34282+1
20073+1
10872-1
10892-1
19043+1
3820-1
77012+1*
3322+1
3125-1
3021-3*
3621-1
3522-2
3419-1
34622+1
40742+1
39642+1
34682+1
9495+2*
9403+1
24102+1
63271-1
96680-1--
5863-1
5874+1
5844+1
5853-1
5802-2
5886+1
5893-1
37022+1
21263+2*
3265-1
3254-1
3293-2
22431-1
27972+1
4695+1
4683-1
24742+1
24722+1
24711-1
24781-1
78712+1
29042+1
5623-1
4817-1
4918+3*
4617-1
4720+2
4416-1
432-2*
4018-1
4111-10*
3465+1
3479+5*
3405+1
3415+1
3484-1
3494-1
22691-1
22621-1
22641-1
94380-1--
94390-1--
94340-1--
20401-1
4004+1
13793+1
4085+1
24591-1
24581-1
24571-1
24532+1
104080-1--
96230-1--
15093+1
19694+2*
28712+1
5475+1
5443-1
5483-1
5493-1
3682-4*
3694-1
3675+1
3654-1
3625+1
22021-1
94360-1--
94370-1--
5915-1
5416-1
5715-2
5116-2
5015-1
4223-1
4256+2
23311-1
24391-1
24323+1
24362+1
24351-1
24342+1
28562+1
5274+1
12323+1
12383+1
19644+2*
84630-1--
84660-1--
84640-1--
84650-1--
84680-1--
22281-1
20891-1
20863+1
10092-1
10063+1
10052-1
10044+1
35702+1
26663+2*
26601-1
18251-1
24172+1
21403+1
32782+1
6018+2
6214-1
6317+1
6415+1
6519+4*
6617+1
6914+1
5083-2*
5075+2
5023-1
5032-2*
12123+1
6374+2*
38692+1
38612+1
41522+1*
26061-1
26002+1
26032+1
100340-1--
37802+1
66592+1*
23811-1
23841-1
23882+1
12792-1
6194+1
33321-1
25973+2
25902+1
25982+1
10701-1
26282+1
100160-1--
7613-2
7515+1
7212-3
7112-1
7013-2
53632+1
10412-1
10472-1
10452-1
10442-1
10492-1
27541-1
23241-1
23651-1
23631-1
23621-1
21091-1
21011-1
21042+1*
948-1
8942-1
8982-1
8992-1
17871-1
6774+1
76090-1--
76080-1--
76060-1--
76050-1--
76040-1--
76020-1--
76010-1--
84670-1--
24971-1
24961-1
84690-1--
15243+1
15224+2
26402+1
26412+1
90770-1--
90740-1--
90750-1--
90720-1--
90730-1--
90780-1--
90790-1--
23452+1
23471-1
23411-1
23404+3*
18831-1
21203+1
1338-1
13111+2
1308-1
13811+1
183+6*
96800-1--
96830-1--
96820-1--
96850-1--
96840-1--
8912-1
8313-7*
8112-1
8714+1
8510-2
15053+1
6594+1
38850-1--
38870-1--
38860-1--
38890-1--
12962-1
12973+1
9902-1
73992+1*
9983+1
90980-1--
90990-1--
90940-1--
90950-1--
90960-1--
90970-1--
90900-1--
90910-1--
90920-1--
90930-1--
35792+1
26692+1
7315+2*
7394+1
23253+2*
23291-1
12953+1
11511+1
1149-1
1169-1
1119-1
11910+1
84800-1--
84810-1--
84820-1--
84830-1--
84840-1--
84850-1--
84870-1--
84880-1--
84890-1--
Family IDGO IDGO term# genes w/ GO ID
9077GO:0003743translation initiation factor activity1/1(6)
9075GO:0000287magnesium ion binding1/1(6)
9072GO:0016020membrane1/1(6)
9073GO:0007605sensory perception of sound1/1(6)
9078GO:0033617mitochondrial respiratory chain complex IV assembly1/2(6)
9079GO:0016020membrane1/1(6)
2363GO:0005737cytoplasm2/2(12)
1524GO:0004360glutamine-fructose-6-phosphate transaminase (isomerizing) activity3/4(16)
7605GO:0000166nucleotide binding1/2(8)
4142GO:0016787hydrolase activity1/2(8)
819GO:0032007negative regulation of TOR signaling2/6(23)
819GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process1/6(23)
819GO:0008526phosphatidylinositol transporter activity2/6(23)
346GO:0003700transcription factor activity, sequence-specific DNA binding1/8(35)
346GO:0046983protein dimerization activity1/8(35)
346GO:0003677DNA binding1/8(35)
346GO:0001046core promoter sequence-specific DNA binding1/8(35)
347GO:0000166nucleotide binding4/7(35)
340GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding3/8(35)
341GO:0003824catalytic activity3/9(35)
341GO:0005739mitochondrion1/9(35)
814GO:0043515kinetochore binding1/5(23)
814GO:0002162dystroglycan binding1/5(23)
349GO:0000166nucleotide binding5/8(34)
8468GO:0016020membrane2/2(7)
1068GO:0008270zinc ion binding2/4(19)
422GO:0008375acetylglucosaminyltransferase activity5/10(32)
2317GO:0003700transcription factor activity, sequence-specific DNA binding3/6(13)
1067GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding2/4(19)
1067GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding2/4(19)
2311GO:0016020membrane2/4(13)
296GO:0005096GTPase activator activity1/10(39)
296GO:0008289lipid binding2/10(39)
296GO:0007165signal transduction2/10(39)
294GO:0003677DNA binding3/9(39)
1662GO:0044822poly(A) RNA binding2/2(16)
1087GO:0046873metal ion transmembrane transporter activity2/4(19)
1087GO:0005385zinc ion transmembrane transporter activity1/4(19)
1129GO:0030957Tat protein binding2/5(18)
1129GO:0006914autophagy1/5(18)
1129GO:0031625ubiquitin protein ligase binding2/5(18)
593GO:0004303estradiol 17-beta-dehydrogenase activity2/7(26)
593GO:0016491oxidoreductase activity2/7(26)
1089GO:0070062extracellular exosome1/4(19)
270GO:0055085transmembrane transport2/10(41)
270GO:0008273calcium, potassium:sodium antiporter activity3/10(41)
270GO:0005262calcium channel activity2/10(41)
274GO:0004062aryl sulfotransferase activity2/12(41)
274GO:0004027alcohol sulfotransferase activity1/12(41)
274GO:0008146sulfotransferase activity5/12(41)
2821GO:0003993acid phosphatase activity2/2(9)
2543GO:0004175endopeptidase activity2/2(11)
2542GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds2/2(11)
3380GO:0003341cilium movement1/2(9)
2381GO:0010314phosphatidylinositol-5-phosphate binding1/2(12)
2269GO:0004103choline kinase activity1/2(13)
1018GO:0000166nucleotide binding2/5(20)
2281GO:0004672protein kinase activity2/2(13)
1014GO:0005886plasma membrane1/4(20)
1015GO:0003676nucleic acid binding5/6(20)
1010GO:0016740transferase activity1/4(20)
1010GO:0004142diacylglycerol cholinephosphotransferase activity2/4(20)
1012GO:0003713transcription coactivator activity1/3(20)
1012GO:0000398mRNA splicing, via spliceosome1/3(20)
1103GO:0003779actin binding1/4(19)
2440GO:0008565protein transporter activity2/2(11)
2441GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds2/2(11)
2447GO:0030374ligand-dependent nuclear receptor transcription coactivator activity2/2(11)
1232GO:0009897external side of plasma membrane1/4(18)
1232GO:0016020membrane1/4(18)
443GO:0003700transcription factor activity, sequence-specific DNA binding1/7(32)
443GO:0003677DNA binding1/7(32)
441GO:0004871signal transducer activity3/7(32)
2189GO:0003677DNA binding3/4(14)
446GO:0005089Rho guanyl-nucleotide exchange factor activity1/4(32)
100GO:0005215transporter activity17/23(90)
100GO:0022857transmembrane transporter activity1/23(90)
101GO:0016020membrane2/23(89)
2101GO:00055451-phosphatidylinositol binding2/4(14)
104GO:0004930G-protein coupled receptor activity2/28(87)
104GO:0004871signal transducer activity3/28(87)
105GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/26(85)
105GO:0003677DNA binding16/26(85)
38GO:0070062extracellular exosome3/36(156)
38GO:0005102receptor binding7/36(156)
38GO:0003735structural constituent of ribosome1/36(156)
38GO:0008061chitin binding1/36(156)
38GO:0008233peptidase activity2/36(156)
38GO:0004857enzyme inhibitor activity1/36(156)
33GO:0000166nucleotide binding26/44(168)
31GO:0004252serine-type endopeptidase activity2/24(171)
31GO:0001964startle response2/24(171)
31GO:0016020membrane2/24(171)
31GO:0008344adult locomotory behavior2/24(171)
31GO:0003682chromatin binding1/24(171)
909GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activity3/7(22)
36GO:0005112Notch binding10/30(160)
36GO:0001047core promoter binding1/30(160)
36GO:0005509calcium ion binding5/30(160)
35GO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding2/37(166)
35GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding6/37(166)
35GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/37(166)
35GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding1/37(166)
35GO:0003677DNA binding3/37(166)
34GO:0001948glycoprotein binding1/45(166)
34GO:0005178integrin binding1/45(166)
34GO:0005102receptor binding2/45(166)
34GO:0005509calcium ion binding28/45(166)
1243GO:0005542folic acid binding1/4(17)
642GO:0000166nucleotide binding5/6(25)
1532GO:0006355regulation of transcription, DNA-templated2/2(16)
647GO:0004175endopeptidase activity1/4(25)
647GO:0004222metalloendopeptidase activity1/4(25)
2487GO:0043995histone acetyltransferase activity (H4-K5 specific)1/2(11)
1248GO:0035091phosphatidylinositol binding1/4(17)
1248GO:0001654eye development1/4(17)
1248GO:0010314phosphatidylinositol-5-phosphate binding1/4(17)
432GO:0005085guanyl-nucleotide exchange factor activity2/6(32)
431GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/9(32)
431GO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding1/9(32)
431GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/9(32)
431GO:0003677DNA binding1/9(32)
2615GO:0008017microtubule binding1/2(10)
339GO:0005347ATP transmembrane transporter activity3/8(35)
339GO:0006810transport1/8(35)
330GO:0005216ion channel activity2/8(36)
8464GO:0003735structural constituent of ribosome2/2(7)
8465GO:0016020membrane2/2(7)
9632GO:0016020membrane1/1(4)
8469GO:0055085transmembrane transport1/2(7)
9635GO:0005783endoplasmic reticulum2/2(4)
3452GO:0003729mRNA binding2/2(9)
6GO:0005200structural constituent of cytoskeleton1/103(437)
6GO:1990126retrograde transport, endosome to plasma membrane2/103(437)
6GO:0007165signal transduction2/103(437)
6GO:0003676nucleic acid binding2/103(437)
6GO:0003950NAD+ ADP-ribosyltransferase activity2/103(437)
6GO:0035556intracellular signal transduction1/103(437)
6GO:0000122negative regulation of transcription from RNA polymerase II promoter1/103(437)
6GO:0000149SNARE binding1/103(437)
6GO:0019887protein kinase regulator activity1/103(437)
6GO:0004672protein kinase activity2/103(437)
6GO:0008134transcription factor binding2/103(437)
6GO:0090090negative regulation of canonical Wnt signaling pathway3/103(437)
6GO:0044212transcription regulatory region DNA binding1/103(437)
6GO:0005216ion channel activity2/103(437)
6GO:0017137Rab GTPase binding1/103(437)
6GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity2/103(437)
6GO:0045893positive regulation of transcription, DNA-templated2/103(437)
6GO:0007520myoblast fusion2/103(437)
6GO:0001085RNA polymerase II transcription factor binding2/103(437)
6GO:0010613positive regulation of cardiac muscle hypertrophy1/103(437)
6GO:0008093cytoskeletal adaptor activity1/103(437)
6GO:0016567protein ubiquitination3/103(437)
6GO:0005634nucleus2/103(437)
3892GO:0003677DNA binding1/2(9)
98GO:0015171amino acid transmembrane transporter activity16/19(91)
91GO:0042813Wnt-activated receptor activity1/25(96)
91GO:0004888transmembrane signaling receptor activity12/25(96)
90GO:0005198structural molecule activity18/37(97)
95GO:0004842ubiquitin-protein transferase activity1/21(95)
95GO:0008270zinc ion binding5/21(95)
97GO:0003958NADPH-hemoprotein reductase activity3/19(91)
97GO:0005272sodium channel activity3/19(91)
97GO:0005261cation channel activity1/19(91)
97GO:0004517nitric-oxide synthase activity3/19(91)
1990GO:0004867serine-type endopeptidase inhibitor activity1/5(15)
348GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding4/9(35)
348GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding1/9(35)
3964GO:0004757sepiapterin reductase activity1/1(8)
2866GO:0016020membrane1/2(9)
2867GO:0005525GTP binding1/2(9)
554GO:0016787hydrolase activity2/8(27)
554GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds2/8(27)
553GO:0003723RNA binding3/4(28)
552GO:0001047core promoter binding1/6(28)
239GO:0003677DNA binding7/9(44)
235GO:0015186L-glutamine transmembrane transporter activity2/11(46)
235GO:0016020membrane4/11(46)
235GO:0005290L-histidine transmembrane transporter activity1/11(46)
235GO:0015171amino acid transmembrane transporter activity2/11(46)
235GO:0005886plasma membrane1/11(46)
237GO:0016740transferase activity2/15(45)
237GO:0004307ethanolaminephosphotransferase activity1/15(45)
2943GO:0005524ATP binding1/2(9)
233GO:0005178integrin binding1/10(46)
233GO:0005201extracellular matrix structural constituent1/10(46)
2345GO:0003824catalytic activity2/4(12)
2345GO:0000166nucleotide binding2/4(12)
1051GO:0005267potassium channel activity2/5(20)
1051GO:0005249voltage-gated potassium channel activity2/5(20)
1052GO:0003824catalytic activity2/4(20)
1053GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding3/5(20)
2341GO:0003682chromatin binding1/3(12)
2341GO:0008270zinc ion binding2/3(12)
1056GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/4(19)
1056GO:0003713transcription coactivator activity2/4(19)
1379GO:0005737cytoplasm1/4(17)
1379GO:0005576extracellular region1/4(17)
1GO:0001223transcription coactivator binding2/267(729)
1GO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding3/267(729)
1GO:0000976transcription regulatory region sequence-specific DNA binding1/267(729)
1GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding6/267(729)
1GO:0003676nucleic acid binding66/267(729)
1GO:0001046core promoter sequence-specific DNA binding1/267(729)
1GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9/267(729)
1GO:0001078transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding2/267(729)
1GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/267(729)
146GO:0016787hydrolase activity7/16(61)
146GO:0004771sterol esterase activity1/16(61)
146GO:0016788hydrolase activity, acting on ester bonds1/16(61)
1279GO:0000185activation of MAPKKK activity1/3(17)
619GO:0016020membrane1/7(26)
619GO:0007275multicellular organism development1/7(26)
619GO:0050885neuromuscular process controlling balance1/7(26)
1172GO:0005518collagen binding2/3(18)
140GO:0000150recombinase activity1/6(64)
140GO:0000166nucleotide binding2/6(64)
612GO:0005216ion channel activity2/8(26)
613GO:0004445inositol-polyphosphate 5-phosphatase activity1/7(26)
2347GO:0000166nucleotide binding3/3(12)
148GO:0016337single organismal cell-cell adhesion2/15(60)
148GO:0045296cadherin binding1/15(60)
148GO:0007043cell-cell junction assembly1/15(60)
148GO:0005102receptor binding1/15(60)
148GO:0005521lamin binding2/15(60)
148GO:0007275multicellular organism development2/15(60)
9440GO:0044822poly(A) RNA binding1/2(5)
3702GO:0003684damaged DNA binding1/2(9)
1005GO:0019955cytokine binding3/5(20)
1286GO:0042327positive regulation of phosphorylation3/4(17)
1280GO:0047757chondroitin-glucuronate 5-epimerase activity2/4(17)
1280GO:0008146sulfotransferase activity1/4(17)
1289GO:0015197peptide transporter activity2/4(17)
1288GO:0003676nucleic acid binding2/2(17)
940GO:0004871signal transducer activity3/11(22)
2506GO:0005244voltage-gated ion channel activity2/2(11)
1475GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity1/6(17)
1475GO:0008373sialyltransferase activity2/6(17)
684GO:0050807regulation of synapse organization2/6(25)
687GO:0005089Rho guanyl-nucleotide exchange factor activity1/4(25)
687GO:0005085guanyl-nucleotide exchange factor activity2/4(25)
2536GO:0003824catalytic activity1/2(11)
2536GO:0004766spermidine synthase activity1/2(11)
2659GO:0014066regulation of phosphatidylinositol 3-kinase signaling1/2(10)
2658GO:0044822poly(A) RNA binding1/2(10)
2716GO:0003729mRNA binding2/3(10)
2650GO:0044822poly(A) RNA binding2/3(10)
1308GO:0005102receptor binding2/4(17)
133GO:0004181metallocarboxypeptidase activity6/16(67)
133GO:0004180carboxypeptidase activity3/16(67)
133GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/16(67)
131GO:0005216ion channel activity7/13(69)
131GO:0005249voltage-gated potassium channel activity1/13(69)
8502GO:0004842ubiquitin-protein transferase activity1/2(7)
138GO:0014719skeletal muscle satellite cell activation2/12(64)
138GO:0005509calcium ion binding1/12(64)
493GO:0002009morphogenesis of an epithelium2/6(29)
493GO:0005509calcium ion binding1/6(29)
493GO:0007154cell communication1/6(29)
24GO:0008233peptidase activity2/54(230)
24GO:0004175endopeptidase activity4/54(230)
24GO:0004222metalloendopeptidase activity16/54(230)
25GO:0004930G-protein coupled receptor activity13/66(229)
25GO:0001631cysteinyl leukotriene receptor activity2/66(229)
25GO:0001965G-protein alpha-subunit binding1/66(229)
25GO:0001530lipopolysaccharide binding2/66(229)
25GO:0004871signal transducer activity24/66(229)
26GO:0005200structural constituent of cytoskeleton54/166(216)
21GO:0001221transcription cofactor binding1/62(240)
21GO:0001046core promoter sequence-specific DNA binding2/62(240)
21GO:0000166nucleotide binding1/62(240)
21GO:0001105RNA polymerase II transcription coactivator activity2/62(240)
21GO:0003676nucleic acid binding5/62(240)
21GO:0003677DNA binding6/62(240)
21GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3/62(240)
21GO:0003682chromatin binding3/62(240)
21GO:0005524ATP binding12/62(240)
23GO:0000287magnesium ion binding2/61(232)
23GO:0004672protein kinase activity17/61(232)
23GO:0000166nucleotide binding18/61(232)
28GO:0048675axon extension2/39(187)
28GO:0002292T cell differentiation involved in immune response1/39(187)
28GO:0070062extracellular exosome1/39(187)
28GO:0016020membrane4/39(187)
28GO:0004888transmembrane signaling receptor activity2/39(187)
28GO:0004872receptor activity1/39(187)
28GO:0005886plasma membrane2/39(187)
28GO:0001843neural tube closure1/39(187)
28GO:0030215semaphorin receptor binding6/39(187)
8491GO:0004842ubiquitin-protein transferase activity2/2(7)
938GO:0003677DNA binding1/5(22)
8497GO:00038684-hydroxyphenylpyruvate dioxygenase activity1/2(7)
8494GO:0003676nucleic acid binding2/2(7)
933GO:0016567protein ubiquitination2/7(22)
933GO:0035556intracellular signal transduction1/7(22)
8499GO:0032418lysosome localization2/2(7)
2016GO:0003824catalytic activity1/3(15)
934GO:0001975response to amphetamine1/6(22)
934GO:0055085transmembrane transport2/6(22)
934GO:0015238drug transmembrane transporter activity1/6(22)
3939GO:0050431transforming growth factor beta binding1/2(8)
2598GO:0005125cytokine activity1/3(10)
829GO:0003779actin binding1/6(23)
829GO:0006914autophagy2/6(23)
829GO:0006897endocytosis2/6(23)
825GO:0005096GTPase activator activity2/6(23)
825GO:0007165signal transduction1/6(23)
825GO:0002011morphogenesis of an epithelial sheet1/6(23)
824GO:0003824catalytic activity4/6(23)
824GO:0031005filamin binding2/6(23)
827GO:0000386second spliceosomal transesterification activity1/2(23)
826GO:0016020membrane5/6(23)
821GO:0003723RNA binding3/6(23)
377GO:0004872receptor activity4/8(33)
376GO:0000122negative regulation of transcription from RNA polymerase II promoter1/8(33)
708GO:0008017microtubule binding3/5(24)
708GO:0005622intracellular1/5(24)
2904GO:0004003ATP-dependent DNA helicase activity1/2(9)
705GO:0005085guanyl-nucleotide exchange factor activity1/6(25)
393GO:0016020membrane1/8(33)
89GO:0000166nucleotide binding9/18(97)
6146GO:0031625ubiquitin protein ligase binding1/1(8)
83GO:0016020membrane3/5(101)
1066GO:0003735structural constituent of ribosome1/3(19)
1066GO:0006396RNA processing1/3(19)
87GO:0005215transporter activity5/20(97)
87GO:0022857transmembrane transporter activity5/20(97)
87GO:0005275amine transmembrane transporter activity2/20(97)
87GO:0015226carnitine transmembrane transporter activity1/20(97)
85GO:0004866endopeptidase inhibitor activity13/25(99)
2301GO:0016020membrane2/5(13)
9388GO:0001567cholesterol 25-hydroxylase activity1/2(5)
798GO:0016020membrane1/6(24)
798GO:0005254chloride channel activity1/6(24)
7GO:0000166nucleotide binding21/107(435)
7GO:0000287magnesium ion binding5/107(435)
7GO:0004672protein kinase activity29/107(435)
8485GO:0009055electron carrier activity2/2(7)
586GO:0016307phosphatidylinositol phosphate kinase activity3/5(27)
587GO:0000166nucleotide binding2/5(27)
584GO:0004415hyalurononglucosaminidase activity2/7(27)
584GO:0098641cadherin binding involved in cell-cell adhesion2/7(27)
585GO:0004252serine-type endopeptidase activity4/6(27)
580GO:0004888transmembrane signaling receptor activity4/5(27)
580GO:0003725double-stranded RNA binding1/5(27)
1133GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3/4(18)
3747GO:0005215transporter activity1/2(9)
1131GO:0000166nucleotide binding1/5(18)
2283GO:0003676nucleic acid binding3/3(13)
1136GO:0008168methyltransferase activity2/4(18)
1135GO:0003676nucleic acid binding3/4(18)
1134GO:0003677DNA binding2/4(18)
244GO:0008233peptidase activity4/10(44)
244GO:0001968fibronectin binding1/10(44)
247GO:0005034osmosensor activity1/13(44)
247GO:0005216ion channel activity8/13(44)
3156GO:0004175endopeptidase activity2/2(9)
243GO:0005509calcium ion binding1/9(44)
243GO:0019899enzyme binding1/9(44)
243GO:0002175protein localization to paranode region of axon1/9(44)
3154GO:0007218neuropeptide signaling pathway1/1(9)
2276GO:0003824catalytic activity1/3(13)
2574GO:0008168methyltransferase activity1/2(10)
1009GO:0005102receptor binding1/3(20)
2374GO:0016020membrane1/2(12)
1006GO:0001933negative regulation of protein phosphorylation1/6(20)
513GO:0003677DNA binding1/6(29)
513GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding2/6(29)
513GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/6(29)
1004GO:0008270zinc ion binding1/3(20)
515GO:0005856cytoskeleton1/6(29)
515GO:0030674protein binding, bridging1/6(29)
515GO:0090162establishment of epithelial cell polarity1/6(29)
2372GO:0019905syntaxin binding2/3(12)
516GO:0000287magnesium ion binding2/5(29)
516GO:0004672protein kinase activity1/5(29)
1349GO:0005315inorganic phosphate transmembrane transporter activity2/4(17)
1349GO:0004871signal transducer activity2/4(17)
621GO:0004308exo-alpha-sialidase activity3/6(26)
620GO:0000976transcription regulatory region sequence-specific DNA binding2/7(26)
620GO:0030259lipid glycosylation1/7(26)
620GO:0000989transcription factor activity, transcription factor binding2/7(26)
2459GO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity2/2(11)
8504GO:0030550acetylcholine receptor inhibitor activity2/3(7)
625GO:0005506iron ion binding1/6(26)
625GO:0004051arachidonate 5-lipoxygenase activity1/6(26)
451GO:0007015actin filament organization1/6(31)
2457GO:0003676nucleic acid binding1/2(11)
628GO:0016020membrane1/6(25)
628GO:0051965positive regulation of synapse assembly4/6(25)
454GO:0005198structural molecule activity5/7(31)
1229GO:0008270zinc ion binding2/5(18)
179GO:0000166nucleotide binding5/10(55)
176GO:0016787hydrolase activity4/12(56)
176GO:0008017microtubule binding4/12(56)
176GO:0004157dihydropyrimidinase activity2/12(56)
175GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/9(56)
175GO:0003677DNA binding2/9(56)
170GO:0006955immune response5/24(57)
2055GO:0044822poly(A) RNA binding1/4(15)
2054GO:0003824catalytic activity1/2(15)
2GO:0000166nucleotide binding33/155(642)
2GO:0003924GTPase activity35/155(642)
2GO:0005509calcium ion binding2/155(642)
2GO:0005525GTP binding32/155(642)
186GO:0005216ion channel activity11/13(52)
187GO:0005201extracellular matrix structural constituent2/12(52)
184GO:0000226microtubule cytoskeleton organization1/6(55)
185GO:0005543phospholipid binding1/12(54)
185GO:0017137Rab GTPase binding2/12(54)
653GO:0016020membrane2/6(25)
653GO:0070063RNA polymerase binding2/6(25)
1505GO:0005044scavenger receptor activity2/3(16)
2390GO:0004857enzyme inhibitor activity1/2(12)
2089GO:0004095carnitine O-palmitoyltransferase activity2/3(14)
8479GO:0002039p53 binding1/2(7)
8479GO:0008270zinc ion binding1/2(7)
9623GO:0005654nucleoplasm1/1(4)
8474GO:0004930G-protein coupled receptor activity2/2(7)
9093GO:0003824catalytic activity2/2(6)
8471GO:0030250guanylate cyclase activator activity1/2(7)
8470GO:0016020membrane1/2(7)
11GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9/99(347)
11GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/99(347)
11GO:0000976transcription regulatory region sequence-specific DNA binding1/99(347)
11GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding3/99(347)
11GO:0003677DNA binding30/99(347)
10GO:0005509calcium ion binding34/114(380)
13GO:0004984olfactory receptor activity3/94(336)
13GO:0004871signal transducer activity31/94(336)
13GO:0003707steroid hormone receptor activity1/94(336)
12GO:0004930G-protein coupled receptor activity6/93(341)
12GO:0004871signal transducer activity51/93(341)
12GO:0001626nociceptin receptor activity2/93(341)
12GO:0001596angiotensin type I receptor activity2/93(341)
12GO:0003779actin binding2/93(341)
12GO:0001965G-protein alpha-subunit binding1/93(341)
12GO:0002020protease binding2/93(341)
14GO:0003777microtubule motor activity1/81(313)
14GO:0000166nucleotide binding38/81(313)
16GO:0003676nucleic acid binding14/69(264)
16GO:0000166nucleotide binding25/69(264)
19GO:0004890GABA-A receptor activity24/58(244)
19GO:0005230extracellular ligand-gated ion channel activity10/58(244)
19GO:0006811ion transport1/58(244)
18GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs2/66(256)
18GO:0004930G-protein coupled receptor activity1/66(256)
18GO:0001594trace-amine receptor activity1/66(256)
18GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/Go4/66(256)
18GO:0001587Gq/11-coupled serotonin receptor activity2/66(256)
18GO:0001965G-protein alpha-subunit binding2/66(256)
18GO:0004871signal transducer activity28/66(256)
3889GO:0045600positive regulation of fat cell differentiation1/3(9)
3440GO:0000166nucleotide binding2/2(9)
867GO:0002060purine nucleobase binding2/4(23)
867GO:0004645phosphorylase activity2/4(23)
2027GO:0007165signal transduction2/2(15)
659GO:0030387fructosamine-3-kinase activity2/6(25)
886GO:0004871signal transducer activity4/6(22)
2086GO:0003676nucleic acid binding3/3(14)
889GO:0016020membrane1/5(22)
1969GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/3(15)
355GO:0003700transcription factor activity, sequence-specific DNA binding1/7(34)
355GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/7(34)
355GO:0003676nucleic acid binding1/7(34)
326GO:0005432calcium:sodium antiporter activity3/5(36)
325GO:0008277regulation of G-protein coupled receptor protein signaling pathway3/9(36)
329GO:0001665alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity2/10(36)
329GO:0008373sialyltransferase activity3/10(36)
200GO:0016020membrane2/10(50)
2871GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding1/2(9)
2871GO:0003677DNA binding1/2(9)
204GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding3/11(49)
204GO:0046983protein dimerization activity4/11(49)
207GO:0004197cysteine-type endopeptidase activity1/14(49)
207GO:0036459thiol-dependent ubiquitinyl hydrolase activity3/14(49)
207GO:0004843thiol-dependent ubiquitin-specific protease activity3/14(49)
209GO:0009986cell surface3/10(49)
209GO:0016020membrane2/10(49)
3623GO:0004497monooxygenase activity2/2(9)
76GO:0001948glycoprotein binding1/22(105)
76GO:0005576extracellular region1/22(105)
76GO:0001657ureteric bud development2/22(105)
75GO:0005179hormone activity2/25(107)
75GO:0005125cytokine activity2/25(107)
75GO:0004745retinol dehydrogenase activity1/25(107)
75GO:0008083growth factor activity11/25(107)
72GO:0004252serine-type endopeptidase activity2/25(108)
72GO:0016020membrane1/25(108)
72GO:0005044scavenger receptor activity1/25(108)
71GO:0001601peptide YY receptor activity7/30(108)
71GO:0004930G-protein coupled receptor activity2/30(108)
71GO:0004871signal transducer activity14/30(108)
70GO:0004871signal transducer activity15/23(109)
2530GO:0035064methylated histone binding1/2(11)
1043GO:0044822poly(A) RNA binding2/6(20)
1043GO:0098641cadherin binding involved in cell-cell adhesion1/6(20)
1041GO:0001786phosphatidylserine binding2/4(20)
1040GO:0007165signal transduction3/5(20)
65GO:0016020membrane1/24(116)
65GO:0004222metalloendopeptidase activity5/24(116)
65GO:0004872receptor activity2/24(116)
65GO:0005518collagen binding1/24(116)
65GO:0005509calcium ion binding2/24(116)
1045GO:0016567protein ubiquitination1/5(20)
1044GO:0007018microtubule-based movement2/4(20)
1044GO:0030507spectrin binding1/4(20)
2338GO:0005524ATP binding1/3(12)
1049GO:0005783endoplasmic reticulum2/4(20)
2235GO:0051726regulation of cell cycle1/4(13)
3710GO:0003700transcription factor activity, sequence-specific DNA binding2/2(9)
1148GO:0044822poly(A) RNA binding1/3(18)
1296GO:0003677DNA binding2/2(17)
660GO:0004871signal transducer activity4/6(25)
2094GO:0005524ATP binding2/5(14)
2097GO:0005198structural molecule activity2/3(14)
2098GO:0005267potassium channel activity2/4(14)
2525GO:0007126meiotic nuclear division1/3(11)
2524GO:0005198structural molecule activity2/4(11)
2523GO:0003824catalytic activity2/2(11)
2486GO:0003677DNA binding1/2(11)
1915GO:0006810transport3/4(15)
699GO:0000166nucleotide binding2/4(25)
7612GO:0005125cytokine activity2/2(8)
7613GO:0016020membrane1/2(8)
527GO:0006629lipid metabolic process1/8(28)
527GO:0016491oxidoreductase activity4/8(28)
547GO:0003677DNA binding2/4(28)
544GO:0004871signal transducer activity4/8(28)
8GO:0003774motor activity3/108(417)
8GO:0007165signal transduction1/108(417)
8GO:0000146microfilament motor activity8/108(417)
8GO:0000166nucleotide binding38/108(417)
548GO:0005215transporter activity4/7(28)
549GO:0008307structural constituent of muscle1/7(28)
549GO:0005623cell1/7(28)
549GO:0006936muscle contraction2/7(28)
990GO:0048706embryonic skeletal system development1/5(21)
2657GO:0005242inward rectifier potassium channel activity2/2(10)
998GO:0003824catalytic activity4/7(21)
120GO:0004252serine-type endopeptidase activity2/14(75)
120GO:0004175endopeptidase activity4/14(75)
120GO:0002020protease binding1/14(75)
121GO:0002091negative regulation of receptor internalization3/17(74)
121GO:0016020membrane1/17(74)
121GO:0060348bone development2/17(74)
121GO:0051965positive regulation of synapse assembly1/17(74)
121GO:0005518collagen binding1/17(74)
121GO:0001530lipopolysaccharide binding1/17(74)
121GO:0001968fibronectin binding1/17(74)
123GO:0003677DNA binding15/21(73)
124GO:0000166nucleotide binding12/14(73)
125GO:0005201extracellular matrix structural constituent6/22(72)
125GO:0001540beta-amyloid binding1/22(72)
125GO:0005198structural molecule activity1/22(72)
126GO:0008146sulfotransferase activity11/19(71)
2388GO:0005524ATP binding1/3(12)
128GO:0005543phospholipid binding1/12(70)
128GO:0016021integral component of membrane1/12(70)
128GO:0016020membrane2/12(70)
129GO:0003779actin binding1/17(70)
129GO:0005509calcium ion binding13/17(70)
1825GO:0004867serine-type endopeptidase inhibitor activity2/4(16)
2410GO:0003729mRNA binding1/3(11)
2145GO:0004672protein kinase activity1/3(14)
130GO:0001849complement component C1q binding1/14(69)
130GO:0005178integrin binding1/14(69)
130GO:0005201extracellular matrix structural constituent2/14(69)
130GO:0005509calcium ion binding1/14(69)
2415GO:0016020membrane4/5(11)
2264GO:0016020membrane1/3(13)
2417GO:0005852eukaryotic translation initiation factor 3 complex1/4(11)
2417GO:0003723RNA binding1/4(11)
2416GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds1/3(11)
1387GO:0005524ATP binding3/4(17)
418GO:0008565protein transporter activity3/6(32)
9098GO:0044822poly(A) RNA binding1/2(6)
312GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity2/10(37)
9096GO:0005524ATP binding1/2(6)
9097GO:0016020membrane2/2(6)
317GO:0043410positive regulation of MAPK cascade2/7(37)
317GO:0016462pyrophosphatase activity1/7(37)
317GO:0019894kinesin binding2/7(37)
9091GO:0005509calcium ion binding1/2(6)
315GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/7(37)
315GO:0003677DNA binding4/7(37)
314GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/10(37)
314GO:0003676nucleic acid binding5/10(37)
9656GO:0003735structural constituent of ribosome2/2(4)
9714GO:0005525GTP binding1/1(4)
3579GO:0003735structural constituent of ribosome1/2(9)
835GO:0008306associative learning1/4(23)
838GO:0006810transport1/6(23)
838GO:0001786phosphatidylserine binding2/6(23)
3570GO:0005783endoplasmic reticulum1/2(9)
2763GO:0007275multicellular organism development1/3(10)
3GO:0000287magnesium ion binding1/139(535)
3GO:0000166nucleotide binding72/139(535)
3GO:0003779actin binding2/139(535)
3GO:0004713protein tyrosine kinase activity1/139(535)
3GO:0004672protein kinase activity11/139(535)
3GO:0005524ATP binding1/139(535)
368GO:0016491oxidoreductase activity1/6(34)
369GO:0008198ferrous iron binding1/6(34)
367GO:0004181metallocarboxypeptidase activity1/8(34)
365GO:0046983protein dimerization activity2/8(34)
362GO:0000166nucleotide binding7/8(34)
2448GO:0097190apoptotic signaling pathway1/4(11)
2448GO:0008270zinc ion binding1/4(11)
2228GO:0051726regulation of cell cycle2/2(13)
381GO:0000166nucleotide binding2/5(33)
385GO:0004672protein kinase activity1/5(33)
385GO:0000166nucleotide binding4/5(33)
387GO:0008307structural constituent of muscle1/6(33)
387GO:0015278calcium-release channel activity1/6(33)
387GO:0051209release of sequestered calcium ion into cytosol2/6(33)
9398GO:0003735structural constituent of ribosome1/2(5)
2329GO:0043066negative regulation of apoptotic process2/3(12)
2293GO:0005634nucleus2/2(13)
2292GO:0004867serine-type endopeptidase inhibitor activity1/5(13)
2292GO:0003677DNA binding1/5(13)
577GO:0005543phospholipid binding2/7(27)
2439GO:0042803protein homodimerization activity1/2(11)
2294GO:0005159insulin-like growth factor receptor binding1/4(13)
2294GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway2/4(13)
60GO:0005737cytoplasm1/27(120)
60GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/27(120)
60GO:0005200structural constituent of cytoskeleton1/27(120)
60GO:0005524ATP binding1/27(120)
60GO:0000166nucleotide binding9/27(120)
258GO:0000166nucleotide binding3/8(42)
2193GO:0005085guanyl-nucleotide exchange factor activity4/7(14)
64GO:0000166nucleotide binding19/28(116)
2195GO:0004930G-protein coupled receptor activity3/4(13)
66GO:0001085RNA polymerase II transcription factor binding1/22(115)
66GO:0001105RNA polymerase II transcription coactivator activity1/22(115)
66GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1/22(115)
66GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding5/22(115)
66GO:0003677DNA binding5/22(115)
252GO:0019992diacylglycerol binding4/7(42)
252GO:0030742GTP-dependent protein binding1/7(42)
253GO:0004482mRNA (guanine-N7-)-methyltransferase activity1/14(42)
253GO:0003723RNA binding1/14(42)
253GO:0004871signal transducer activity9/14(42)
255GO:0004497monooxygenase activity3/9(42)
2569GO:0016020membrane2/3(10)
2202GO:0005096GTPase activator activity2/3(13)
1427GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/3(17)
3362GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/2(9)
731GO:0008270zinc ion binding1/8(24)
404GO:0003676nucleic acid binding3/7(33)
508GO:0019208phosphatase regulator activity1/5(29)
508GO:0017112Rab guanyl-nucleotide exchange factor activity2/5(29)
2432GO:0001664G-protein coupled receptor binding1/2(11)
739GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity1/6(24)
507GO:0004571mannosyl-oligosaccharide 1,2-alpha-mannosidase activity8/8(29)
2365GO:0045892negative regulation of transcription, DNA-templated2/2(12)
502GO:0000166nucleotide binding4/7(29)
503GO:0003677DNA binding2/6(29)
1034GO:0005543phospholipid binding1/5(20)
1034GO:0005096GTPase activator activity1/5(20)
1212GO:0000149SNARE binding2/5(18)
1212GO:0019905syntaxin binding1/5(18)
632GO:0002046opsin binding3/6(25)
632GO:0005096GTPase activator activity2/6(25)
469GO:0003676nucleic acid binding2/7(30)
2582GO:0006915apoptotic process1/3(10)
637GO:0004888transmembrane signaling receptor activity4/9(25)
637GO:0005149interleukin-1 receptor binding2/9(25)
637GO:0019843rRNA binding1/9(25)
400GO:0008270zinc ion binding7/12(33)
2015GO:0016491oxidoreductase activity3/4(15)
169GO:0009897external side of plasma membrane1/18(57)
169GO:0016020membrane5/18(57)
169GO:0043274phospholipase binding2/18(57)
169GO:0005518collagen binding1/18(57)
165GO:0003677DNA binding20/24(57)
161GO:0003824catalytic activity1/10(57)
161GO:0007165signal transduction1/10(57)
161GO:0042803protein homodimerization activity2/10(57)
162GO:0005216ion channel activity1/9(57)
162GO:0006816calcium ion transport1/9(57)
163GO:0004177aminopeptidase activity3/12(57)
163GO:0008237metallopeptidase activity3/12(57)
163GO:0006508proteolysis1/12(57)
964GO:0005911cell-cell junction1/4(21)
8498GO:0004930G-protein coupled receptor activity2/2(7)
961GO:0006479protein methylation1/5(21)
961GO:0019899enzyme binding1/5(21)
2109GO:0016020membrane1/4(14)
2109GO:0004180carboxypeptidase activity2/4(14)
2519GO:0003824catalytic activity1/2(11)
9438GO:0004842ubiquitin-protein transferase activity1/2(5)
9434GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c2/2(5)
2007GO:0016020membrane1/2(15)
1510GO:0000900translation repressor activity, nucleic acid binding1/3(16)
2104GO:0003725double-stranded RNA binding4/5(14)
2735GO:0051225spindle assembly1/2(10)
30GO:0017147Wnt-protein binding1/37(182)
30GO:0001540beta-amyloid binding1/37(182)
30GO:0005041low-density lipoprotein receptor activity2/37(182)
30GO:0005509calcium ion binding6/37(182)
30GO:0001948glycoprotein binding1/37(182)
2730GO:0005102receptor binding1/2(10)
874GO:0000287magnesium ion binding1/4(23)
875GO:0002244hematopoietic progenitor cell differentiation1/4(23)
873GO:0005078MAP-kinase scaffold activity1/4(23)
870GO:0000166nucleotide binding3/6(23)
9GO:0007626locomotory behavior1/100(386)
9GO:0000070mitotic sister chromatid segregation1/100(386)
9GO:0000902cell morphogenesis2/100(386)
9GO:0005783endoplasmic reticulum1/100(386)
9GO:0006355regulation of transcription, DNA-templated2/100(386)
9GO:0002467germinal center formation2/100(386)
9GO:0051015actin filament binding1/100(386)
9GO:0003779actin binding6/100(386)
9GO:0016567protein ubiquitination8/100(386)
9GO:2001243negative regulation of intrinsic apoptotic signaling pathway1/100(386)
9GO:0007010cytoskeleton organization1/100(386)
9GO:0031397negative regulation of protein ubiquitination2/100(386)
9GO:2000312regulation of kainate selective glutamate receptor activity2/100(386)
9GO:0004842ubiquitin-protein transferase activity4/100(386)
9GO:0006446regulation of translational initiation3/100(386)
9GO:0042802identical protein binding3/100(386)
9GO:0005615extracellular space2/100(386)
2039GO:0000993RNA polymerase II core binding1/5(15)
677GO:0008134transcription factor binding1/6(25)
677GO:0005158insulin receptor binding2/6(25)
677GO:0035014phosphatidylinositol 3-kinase regulator activity1/6(25)
894GO:0003676nucleic acid binding2/4(22)
898GO:0003700transcription factor activity, sequence-specific DNA binding2/6(22)
898GO:0044325ion channel binding2/6(22)
899GO:0004197cysteine-type endopeptidase activity1/6(22)
899GO:0004843thiol-dependent ubiquitin-specific protease activity4/6(22)
809GO:0005201extracellular matrix structural constituent1/4(24)
353GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding2/8(34)
353GO:0003677DNA binding1/8(34)
351GO:0070062extracellular exosome2/5(34)
800GO:0005783endoplasmic reticulum1/4(24)
806GO:0004364glutathione transferase activity8/8(24)
805GO:0006810transport1/6(24)
214GO:0005654nucleoplasm2/13(48)
214GO:0016020membrane4/13(48)
214GO:0007601visual perception2/13(48)
214GO:0051965positive regulation of synapse assembly2/13(48)
212GO:0005216ion channel activity4/7(49)
211GO:0030500regulation of bone mineralization1/11(49)
211GO:0005201extracellular matrix structural constituent1/11(49)
211GO:0005518collagen binding3/11(49)
211GO:0030199collagen fibril organization2/11(49)
211GO:0061303cornea development in camera-type eye2/11(49)
2840GO:0003676nucleic acid binding1/2(9)
219GO:0000166nucleotide binding7/10(48)
3323GO:0003824catalytic activity1/2(9)
1079GO:0030544Hsp70 protein binding2/4(19)
1074GO:0003824catalytic activity2/5(19)
1074GO:0003730mRNA 3'-UTR binding2/5(19)
1070GO:0000166nucleotide binding4/8(19)
4GO:0001948glycoprotein binding1/119(497)
4GO:0004252serine-type endopeptidase activity50/119(497)
4GO:0004175endopeptidase activity2/119(497)
280GO:0044325ion channel binding1/7(40)
1095GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/4(19)
1156GO:0003714transcription corepressor activity1/5(18)
1156GO:0008270zinc ion binding2/5(18)
1099GO:0007186G-protein coupled receptor signaling pathway1/4(19)
1099GO:0004872receptor activity2/4(19)
260GO:0005244voltage-gated ion channel activity3/11(42)
260GO:0004602glutathione peroxidase activity2/11(42)
265GO:0000166nucleotide binding3/11(42)
264GO:0004871signal transducer activity10/12(42)
2553GO:0006810transport2/2(10)
59GO:0004889acetylcholine-activated cation-selective channel activity21/31(122)
7609GO:0000166nucleotide binding3/3(8)
3035GO:0044822poly(A) RNA binding2/2(9)
3036GO:0000287magnesium ion binding1/2(9)
7604GO:0005739mitochondrion2/2(8)
51GO:0048306calcium-dependent protein binding2/31(135)
51GO:0000149SNARE binding3/31(135)
51GO:0006887exocytosis1/31(135)
51GO:0005544calcium-dependent phospholipid binding2/31(135)
51GO:0017158regulation of calcium ion-dependent exocytosis1/31(135)
51GO:0005509calcium ion binding4/31(135)
51GO:0001786phosphatidylserine binding1/31(135)
51GO:0017156calcium ion regulated exocytosis1/31(135)
50GO:0055077gap junction hemi-channel activity2/43(137)
50GO:0001568blood vessel development1/43(137)
50GO:0001508action potential1/43(137)
50GO:0004871signal transducer activity2/43(137)
50GO:0002088lens development in camera-type eye1/43(137)
50GO:0007154cell communication12/43(137)
50GO:0005243gap junction channel activity4/43(137)
50GO:0005216ion channel activity2/43(137)
50GO:0042803protein homodimerization activity2/43(137)
7601GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds1/2(8)
3033GO:0044822poly(A) RNA binding2/2(9)
2396GO:0070062extracellular exosome1/4(12)
535GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/6(28)
535GO:0003676nucleic acid binding2/6(28)
63GO:0001641group II metabotropic glutamate receptor activity4/24(116)
63GO:0004871signal transducer activity8/24(116)
2259GO:0019899enzyme binding1/3(13)
54GO:0000166nucleotide binding20/33(131)
408GO:0005524ATP binding2/8(33)
1295GO:0004867serine-type endopeptidase inhibitor activity1/4(17)
57GO:0000166nucleotide binding21/30(129)
538GO:0004167dopachrome isomerase activity2/6(28)
538GO:0005507copper ion binding2/6(28)
538GO:0004503monophenol monooxygenase activity2/6(28)
1322GO:0004843thiol-dependent ubiquitin-specific protease activity1/4(17)
988GO:0000149SNARE binding4/6(21)
988GO:0019905syntaxin binding1/6(21)
2474GO:0005634nucleus1/3(11)
2471GO:0016857racemase and epimerase activity, acting on carbohydrates and derivatives1/2(11)
984GO:0001530lipopolysaccharide binding2/6(21)
7602GO:0003713transcription coactivator activity1/3(8)
115GO:0005102receptor binding11/20(79)
114GO:0004620phospholipase activity8/22(79)
116GO:0017154semaphorin receptor activity7/21(78)
111GO:0005201extracellular matrix structural constituent1/21(82)
111GO:0005615extracellular space3/21(82)
111GO:0044822poly(A) RNA binding1/21(82)
111GO:0031012extracellular matrix2/21(82)
111GO:0002020protease binding1/21(82)
111GO:0035987endodermal cell differentiation2/21(82)
69GO:0003779actin binding5/25(109)
69GO:0003725double-stranded RNA binding1/25(109)
69GO:0005509calcium ion binding3/25(109)
2496GO:0019894kinesin binding1/2(11)
119GO:0016787hydrolase activity4/22(75)
119GO:0042043neurexin family protein binding4/22(75)
119GO:0003990acetylcholinesterase activity2/22(75)
119GO:0004771sterol esterase activity1/22(75)
1904GO:0046873metal ion transmembrane transporter activity1/3(15)
1904GO:0005385zinc ion transmembrane transporter activity1/3(15)
2782GO:0005125cytokine activity2/2(10)
1256GO:0003824catalytic activity1/4(17)
918GO:0016020membrane1/4(22)
918GO:0001525angiogenesis1/4(22)
1522GO:0014065phosphatidylinositol 3-kinase signaling1/2(16)
915GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2/5(22)
2070GO:0019901protein kinase binding2/4(15)
2070GO:0002020protease binding2/4(15)
425GO:0008375acetylglucosaminyltransferase activity3/5(32)
425GO:0015020glucuronosyltransferase activity1/5(32)
2075GO:0044822poly(A) RNA binding1/2(14)
2600GO:0005521lamin binding1/3(10)
3817GO:0004672protein kinase activity2/2(9)
9088GO:0005262calcium channel activity1/2(6)
9086GO:0019894kinesin binding2/2(6)
305GO:0015020glucuronosyltransferase activity1/17(38)
1935GO:0003700transcription factor activity, sequence-specific DNA binding1/6(15)
842GO:0005543phospholipid binding2/6(23)
842GO:0048156tau protein binding1/6(23)
841GO:0007155cell adhesion1/3(23)
62GO:0003779actin binding4/29(119)
62GO:0005509calcium ion binding11/29(119)
2567GO:0003723RNA binding1/3(10)
589GO:0015018galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity4/7(27)
568GO:0005246calcium channel regulator activity1/5(27)
562GO:0003682chromatin binding1/6(27)
562GO:0000166nucleotide binding2/6(27)
2182GO:0005021vascular endothelial growth factor-activated receptor activity3/4(14)
2186GO:0090002establishment of protein localization to plasma membrane2/3(14)
2185GO:0004812aminoacyl-tRNA ligase activity2/4(14)
1047GO:0003677DNA binding4/4(20)
225GO:0005215transporter activity8/12(48)
225GO:0001972retinoic acid binding2/12(48)
224GO:0004872receptor activity5/11(48)
221GO:0004180carboxypeptidase activity9/14(48)
2953GO:0004888transmembrane signaling receptor activity2/2(9)
1187GO:0001948glycoprotein binding1/5(18)
1187GO:0015031protein transport1/5(18)
723GO:0003824catalytic activity3/4(24)
2355GO:0005249voltage-gated potassium channel activity2/3(12)
150GO:0001948glycoprotein binding2/16(60)
150GO:0004872receptor activity7/16(60)
150GO:0001968fibronectin binding1/16(60)
153GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1/13(59)
153GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/13(59)
153GO:0003676nucleic acid binding5/13(59)
157GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding4/13(58)
157GO:0000979RNA polymerase II core promoter sequence-specific DNA binding2/13(58)
157GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding1/13(58)
157GO:0003677DNA binding2/13(58)
159GO:0000166nucleotide binding1/9(58)
158GO:0003779actin binding4/14(58)
158GO:0005523tropomyosin binding5/14(58)
1200GO:0000166nucleotide binding3/4(18)
3733GO:0008009chemokine activity2/2(9)
468GO:0005319lipid transporter activity4/10(31)
81GO:0003779actin binding1/27(102)
81GO:0005856cytoskeleton4/27(102)
81GO:0010592positive regulation of lamellipodium assembly1/27(102)
81GO:0004721phosphoprotein phosphatase activity2/27(102)
81GO:0008092cytoskeletal protein binding2/27(102)
48GO:0004842ubiquitin-protein transferase activity18/35(139)
48GO:0003713transcription coactivator activity2/35(139)
49GO:0003777microtubule motor activity11/30(138)
46GO:0004435phosphatidylinositol phospholipase C activity14/34(146)
46GO:0001786phosphatidylserine binding2/34(146)
47GO:0001085RNA polymerase II transcription factor binding2/33(141)
47GO:0000976transcription regulatory region sequence-specific DNA binding2/33(141)
47GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding4/33(141)
47GO:0003677DNA binding3/33(141)
47GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding5/33(141)
47GO:0000979RNA polymerase II core promoter sequence-specific DNA binding1/33(141)
44GO:0004497monooxygenase activity26/47(148)
44GO:0005506iron ion binding2/47(148)
955GO:0030159receptor signaling complex scaffold activity1/4(21)
40GO:0003924GTPase activity9/40(152)
40GO:0004871signal transducer activity3/40(152)
40GO:0005525GTP binding19/40(152)
41GO:0000166nucleotide binding2/52(151)
41GO:0004672protein kinase activity6/52(151)
1111GO:0016884carbon-nitrogen ligase activity, with glutamine as amido-N-donor4/6(19)
9428GO:0005654nucleoplasm1/1(5)
476GO:0004871signal transducer activity4/8(30)
2503GO:0005509calcium ion binding1/2(11)
1297GO:0017147Wnt-protein binding1/4(17)
2500GO:0003677DNA binding1/1(11)
2640GO:0004842ubiquitin-protein transferase activity2/3(10)
2641GO:0008270zinc ion binding1/3(10)
488GO:0032947protein complex scaffold3/8(30)
486GO:0003700transcription factor activity, sequence-specific DNA binding1/9(30)
486GO:0003682chromatin binding1/9(30)
484GO:0005215transporter activity6/7(30)
484GO:0008289lipid binding1/7(30)
483GO:0008013beta-catenin binding1/6(30)
3428GO:0003723RNA binding2/2(9)
8480GO:0008375acetylglucosaminyltransferase activity2/2(7)
471GO:0005615extracellular space2/8(30)
471GO:0001968fibronectin binding1/8(30)
471GO:0003190atrioventricular valve formation2/8(30)
1362GO:0005078MAP-kinase scaffold activity2/4(17)
1362GO:0008432JUN kinase binding1/4(17)
477GO:0003779actin binding1/4(30)
477GO:0050699WW domain binding2/4(30)
475GO:0008270zinc ion binding1/7(30)
9095GO:0005737cytoplasm2/2(6)